MYOC

Gene Symbol	MYOC
Entrez Gene	4653
Alt Symbol	GLC1A, GPOA, JOAG, JOAG1, TIGR, myocilin
Species	Human
Gene Type	protein-coding
Description	myocilin, trabecular meshwork inducible glucocorticoid response
Other Description	mutated trabecular meshwork-induced glucocorticoid response protein|myocilin|myocilin 55 kDa subunit
Swissprots	O00620 Q7Z6Q9 B2RD84 Q99972
Accessions	AAC14264 AAT09137 BAA24532 CAB09899 EAW90903 Q99972 AF001620 AAC51725 AK097310 BAC04997 AK300924 BAG62556 AK300943 BAG62572 AK301297 BAG62854 AK315443 BAG37831 BC029261 AAH29261 D88214 BAA23531 DQ892415 ABM83341 DQ895629 ABM86555 FJ227302 ACI42983 FJ237046 ACI62292 FJ237047 ACI62293 U85257 AAC52051 NM_000261 NP_000252
Function	Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-assoc
Subcellular Location	Myocilin, N-terminal fragment: Endoplasmic reticulum. Note=Remains retained in the endoplasmic reticulum.
Tissue Specificity	Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, bone marrow-derived mesenchymal stem cells and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma. The myocilin 35 kDa fragment is detected in aqueous humor and at the less extend in iris and ciliary body. {ECO:0000269|PubMed:15795224}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

myocilin CRISPR/Cas9 KO Plasmid (h) - sc-401843 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

myocilin HDR Plasmid (h) - sc-401843-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

myocilin Double Nickase Plasmid (h) - sc-401843-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

myocilin Double Nickase Plasmid (h2) - sc-401843-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

myocilin CRISPR Activation Plasmid (h) - sc-401843-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

myocilin CRISPR Activation Plasmid (h2) - sc-401843-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

myocilin Lentiviral Activation Particles (h) - sc-401843-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

myocilin Lentiviral Activation Particles (h2) - sc-401843-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

myocilin siRNA (h) - sc-40753 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

myocilin shRNA Plasmid (h) - sc-40753-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

myocilin shRNA (h) Lentiviral Particles - sc-40753-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Myocilin RNAi - H00004653-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU083301 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14869 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14869 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04051 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr04051

MYOC siRNA (Human) - CRH3076 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Myocilin RNAi - H00004653-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human MYOC (NM_000261.1) - SHH348356 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human MYOC(NM_000261.1) - SHH213509 from Creative biogene Category siRNA Species Reactivities Human

Human MYOC siRNA - orb263578 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MYOC shRNA Plasmid (Human) - CHH3076 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MYOC miRNA 3'UTR clone - MiUTR1H-06603 from Creative biogene Species Reactivities Human

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