MYOC

Gene Symbol	MYOC
Entrez Gene	4653
Alt Symbol	GLC1A, GPOA, JOAG, JOAG1, TIGR, myocilin
Species	Human
Gene Type	protein-coding
Description	myocilin, trabecular meshwork inducible glucocorticoid response
Other Description	mutated trabecular meshwork-induced glucocorticoid response protein|myocilin|myocilin 55 kDa subunit
Swissprots	O00620 Q7Z6Q9 B2RD84 Q99972
Accessions	AAC14264 AAT09137 BAA24532 CAB09899 EAW90903 Q99972 AF001620 AAC51725 AK097310 BAC04997 AK300924 BAG62556 AK300943 BAG62572 AK301297 BAG62854 AK315443 BAG37831 BC029261 AAH29261 D88214 BAA23531 DQ892415 ABM83341 DQ895629 ABM86555 FJ227302 ACI42983 FJ237046 ACI62292 FJ237047 ACI62293 U85257 AAC52051 NM_000261 NP_000252
Function	Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-assoc
Subcellular Location	Myocilin, N-terminal fragment: Endoplasmic reticulum. Note=Remains retained in the endoplasmic reticulum.
Tissue Specificity	Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, bone marrow-derived mesenchymal stem cells and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma. The myocilin 35 kDa fragment is detected in aqueous humor and at the less extend in iris and ciliary body. {ECO:0000269|PubMed:15795224}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Myocilin full length protein - ab116838 from Abcam Category Protein Source Wheat germ Species Human

Human Myocilin full length protein - ab151657 from Abcam Category Protein Source HEK 293 cells Species Human

Human Myocilin protein fragment - ab116837 from Abcam Category Protein Source Wheat germ Species Human

MYOC / Myocilin Antibody Blocking Peptide - LS-E21878 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Myocilin Protein - H00004653-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Myocilin Recombinant Protein - H00004653-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Human MYOC His tag protein - orb84578 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Human Species Human

Human Myocilin protein - orb49547 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293

Human Myocilin Protein - abx068136 from Abbexa Category Protein Source E.coli Species Human

Myocilin - H00004653-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Myocilin - H00004653-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Myocilin - H00004653-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Myocilin - H00004653-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Myocilin Control Peptide - AP10160CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

Myocilin Control Peptide - AP10161CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

Myocilin Control Peptide - AP10162CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

Myocilin (MYOC), Human - 20-9287 from ARP American Research Products Category Protein Prices $455.00 Sizes 50 µg Source E.coli Species Human

Myocilin, Human, Recombinant - 19-C491 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source HEK293 Species Human

Myocilin Recombinant Protein - 96-549 from ProSci Category Protein Prices $450.00 Sizes 50 µg Source HEK293 cells Species Human

MYOC fusion protein - Ag5492 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Myocilin Protein - BP001766-C491 from Syd Labs Category Protein Prices $126.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human MYOC - MYOC-28653TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human MYOC - MYOC-29758TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human MYOC, His tagged - MYOC-6991H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Myocilin (MYOC) - RPH586Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Search more