MYOC

Gene Symbol	MYOC
Entrez Gene	4653
Alt Symbol	GLC1A, GPOA, JOAG, JOAG1, TIGR, myocilin
Species	Human
Gene Type	protein-coding
Description	myocilin, trabecular meshwork inducible glucocorticoid response
Other Description	mutated trabecular meshwork-induced glucocorticoid response protein|myocilin|myocilin 55 kDa subunit
Swissprots	O00620 Q7Z6Q9 B2RD84 Q99972
Accessions	AAC14264 AAT09137 BAA24532 CAB09899 EAW90903 Q99972 AF001620 AAC51725 AK097310 BAC04997 AK300924 BAG62556 AK300943 BAG62572 AK301297 BAG62854 AK315443 BAG37831 BC029261 AAH29261 D88214 BAA23531 DQ892415 ABM83341 DQ895629 ABM86555 FJ227302 ACI42983 FJ237046 ACI62292 FJ237047 ACI62293 U85257 AAC52051 NM_000261 NP_000252
Function	Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-assoc
Subcellular Location	Myocilin, N-terminal fragment: Endoplasmic reticulum. Note=Remains retained in the endoplasmic reticulum.
Tissue Specificity	Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, bone marrow-derived mesenchymal stem cells and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma. The myocilin 35 kDa fragment is detected in aqueous humor and at the less extend in iris and ciliary body. {ECO:0000269|PubMed:15795224}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MYOC / Myocilin ELISA Kit (Sandwich ELISA) - LS-F6499 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.26 ng/ml Range 0.781-50 ng/ml

Human Myocilin ELISA Kit - abx152433 from Abbexa Category ELISA Kit Sensitivity 0.28 ng/ml Range 0.781 ng/ml - 50 ng/ml

Myocilin (MYOC), Human, ELISA Kit - CSB-EL015356HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.039 U/ml Range 0.156 U/ml-10 U/ml

Myocilin (MYOC), Human, ELISA Kit - SEH586Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.28ng/mL Range 0.78-50ng/mL

MYOC (Human) IP-WB Antibody Pair - H00004653-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

MYOC (Human) Matched Antibody Pair - H00004653-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

MYOC (Human) Matched Antibody Pair - H00004653-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Myocilin, ELISA Kit - MBS101884 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myocilin (MYOC), ELISA Kit - MBS2023214 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.26ng/mL. Range 0.781-50ng/mL

Myocilin (MYOC) - MBS9308524 from MyBioSource Category ELISA Kit Prices $435.00, $600.00 Sizes 48 strip wells, 96 strip wells

myocilin, trabecular meshwork inducible glucocorticoid response, ELISA Kit - MBS912080 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human MYOC is typically less than 0.039 U/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.156 U/ml -10 U/ml.

Myocilin, ELISA Kit - MBS077113 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myocilin, ELISA Kit - MBS051309 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 1.56ng/ml-50ng/ml.

Myocilin, ELISA Kit - MBS055712 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myocilin, ELISA Kit - MBS061109 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myocilin, ELISA Kit - MBS066268 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Myocilin, ELISA Kit - MBS068084 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Myocilin (MYOC) - SEH586Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.26ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Human Myocilin(MYOC) ELISA kit - CSB-EL015356HU from Cusabio Category ELISA Kit Sensitivity 0.039 U/ml Range 0.156 U/ml-10 U/ml

ELISA Kit for Myocilin (MYOC) - SEH586Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.26ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA's were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Human Myocilin (MYOC) ELISA Kit - EKU06072 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.26 ng/mL Range 0.781-50 ng/mL

Myocilin (MYOC), Human, ELISA Kit - DL-MYOC-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.78 -50 ng/mL

Human MYOC ELISA Kit - orb367933 from Biorbyt Category ELISA Kit Prices $553.00, $621.00 Sizes 48 test, 96 test Range Detection Range: 0.781-50ng/mL Detection low threshold: 0.28ng/mL

Human MYOC ELISA Kit - abx573527 from Abbexa Category ELISA Kit Sensitivity 0.28 ng/ml Range 0.781 ng/ml - 50 ng/ml

Human Myocilin (MYOC) ELISA Kit - EKC34701 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.039 U/ml Range 0.156 U/ml-10 U/ml

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