SPG21

Gene Symbol SPG21
Entrez Gene 51324
Alt Symbol ACP33, BM-019, GL010, MAST
Species Human
Gene Type protein-coding
Description spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Other Description acid cluster protein 33|maspardin
Swissprots Q9NZD8 B4DW44 Q6ZMB6
Accessions EAW77704 EAW77705 Q9NZD8 AA179262 AF208861 AAF64275 AF212231 AAK14917 AI161152 AK123725 AK172849 BAD18813 AK225527 AK301362 BAG62906 AK312943 BC000244 AAH00244 BI258560 BI259651 BI552731 BI554234 BI771887 BP268459 BP268875 BX446863 DA680695 DB477175 HQ447370 ADQ31856 XM_005254436 XP_005254493 XM_005254437 XP_005254494 XM_006720564 XP_006720627 XM_011521662 XP_011519964 NM_001127889 NP_001121361 NM_001127890 NP_001121362 NM_016630 NP_057714
Function May play a role as a negative regulatory factor in CD4- dependent T-cell activation. {ECO:0000269|PubMed:11113139}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:11113139}. Membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Endosome membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans- Golgi network.
Tissue Specificity Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level). {ECO:0000269|PubMed:11113139}.

Maspardin (H-5) - sc-393340 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Maspardin (H-5): sc-393340. Western blot analysis of Maspardin expression in HL-60 (A), HuT 78 (B), HeLa (C) and Hep G2 (D) whole cell lysates.

Maspardin (H-67) - sc-367035 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Maspardin (H-67): sc-367035. Western blot analysis of Maspardin expression in A549 whole cell lysate.

Maspardin (Q-17) - sc-83838 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Maspardin (Q-17): sc-83838. Western blot analysis of Maspardin expression in HL-60 whole cell lysate.

Anti-SPG21 antibody - ab133883 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SPG21 antibody (ab133883) at 1 µg/ml + 721_B cell lysate at 10 µg

Anti-SPG21 / MAST Antibody (clone AA1, Azide-free) - LS-C87617 from LifeSpan Bioscience

Prices $575.00, $880.00
Sizes 100 µg, 200 µg
Host Mouse
Clonality Monoclonal
Clone AA1

Anti-CMA1 / MCT1 / Chymase Antibody (clone CC1, Azide-free) - LS-C87619 from LifeSpan Bioscience

Prices $575.00, $860.00
Sizes 100 µg, 200 µg
Host Mouse
Clonality Monoclonal
Clone CC1

Anti-CMA1 / MCT1 / Chymase Antibody (clone CC1) - LS-C87618 from LifeSpan Bioscience

Prices $280.00, $510.00, $810.00
Sizes 8 µg, 40 µg, 1 ml
Host Mouse
Clonality Monoclonal
Clone CC1
Formalin-fixed, paraffin-embedded human tonsil stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of mast cells.

Anti-SPG21 / MAST Antibody (clone AA1) - LS-C87616 from LifeSpan Bioscience

Prices $280.00, $510.00, $810.00
Sizes 5 µg, 500 µl, 50 µg
Host Mouse
Clonality Monoclonal
Clone AA1
Formalin-fixed, paraffin-embedded human tonsil stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of mast cells.

Anti-SPG21 / MAST Antibody (aa217-266) IHC-plus™ - LS-B12044 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-SPG21 / MAST Antibody (C-Terminus) IHC-plus™ - LS-B12043 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

SPG21 Antibody - NBP1-89273 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SPG21 Antibody [NBP1-89273] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

SPG21 Antibody - H00051324-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: SPG21 Antibody [H00051324-A01] - SPG21 polyclonal antibody (A01), Lot # 060516JCS1 Western Blot analysis of SPG21 expression in HL-60 ( Cat # L014V1 ).

SPG21 Antibody (2B11) - H00051324-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B11
Sandwich ELISA: SPG21 Antibody (2B11) [H00051324-M01] - Detection limit for recombinant GST tagged SPG21 is 0.3 ng/ml as a capture antibody.

SPG21 Polyclonal Antibody - bs-11785R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPG21 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11785R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPG21 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11785R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPG21 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11785R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPG21 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11785R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPG21 Polyclonal Antibody, Cy3 Conjugated - bs-11785R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPG21 Polyclonal Antibody, Cy5 Conjugated - bs-11785R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPG21 Polyclonal Antibody, Cy5.5 Conjugated - bs-11785R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPG21 Polyclonal Antibody, Cy7 Conjugated - bs-11785R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPG21 Polyclonal Antibody, FITC Conjugated - bs-11785R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPG21 Polyclonal Antibody, Biotin Conjugated - bs-11785R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPG21 Polyclonal Antibody, HRP Conjugated - bs-11785R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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