SPG21

Gene Symbol	SPG21
Entrez Gene	51324
Alt Symbol	ACP33, BM-019, GL010, MAST
Species	Human
Gene Type	protein-coding
Description	spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Other Description	acid cluster protein 33|maspardin
Swissprots	Q9NZD8 B4DW44 Q6ZMB6
Accessions	EAW77704 EAW77705 Q9NZD8 AA179262 AF208861 AAF64275 AF212231 AAK14917 AI161152 AK123725 AK172849 BAD18813 AK225527 AK301362 BAG62906 AK312943 BC000244 AAH00244 BI258560 BI259651 BI552731 BI554234 BI771887 BP268459 BP268875 BX446863 DA680695 DB477175 HQ447370 ADQ31856 XM_005254436 XP_005254493 XM_005254437 XP_005254494 XM_006720564 XP_006720627 XM_011521662 XP_011519964 NM_001127889 NP_001121361 NM_001127890 NP_001121362 NM_016630 NP_057714
Function	May play a role as a negative regulatory factor in CD4- dependent T-cell activation. {ECO:0000269|PubMed:11113139}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:11113139}. Membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Endosome membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans- Golgi network.
Tissue Specificity	Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level). {ECO:0000269|PubMed:11113139}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SPG21 full length protein - ab86438 from Abcam Category Protein Source E. coli Species Human

SPG21 / MAST Antibody Blocking Peptide - LS-E23912 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPG21 / MAST Antibody Blocking Peptide - LS-E23913 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPG21 Partial Recombinant Protein - H00051324-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SPG21 Recombinant Protein - H00051324-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SPG21 Protein - NBC1-21650 from Novus Biologicals Category Protein Prices $329.00 Sizes 100 µl Species Human

SPG21 Recombinant Protein - GTX48011-PRO from GeneTex Category Protein Prices $329.00 Sizes 50 μg Source E. coli Species Human

SPG21 Protein (OPPA01807) - OPPA01807 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Spastic Paraplegia 21 protein - orb81386 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

SPG21 protein (His tag) - 80R-1128 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

Maspardin (1-308, His-tag) - AR09164PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Maspardin (1-308, His-tag) - AR09164PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Maspardin - H00051324-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Maspardin - H00051324-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Maspardin - H00051324-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Maspardin - H00051324-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Spastic Paraplegia 21, Human Recombinant - 228-11453-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human SPG21 - 228-11453-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human SPG21 - 228-11453-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

SPG21, 1-308 aa, Human, His-tagged, Recombinant, E.coli - 01-2054 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

SPG21 Recombinant Protein - XW-RP3255 from ProSci Category Protein Prices $245.00 Sizes 50 µg Source E. coli Species Human

SPG21 fusion protein - ag14879 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SPG21 fusion protein - ag13851 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SPG21 Human - PRPS-684 from NeoScientific Category Protein Prices $65.00, $169.00, $4,680.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Spastic Paraplegia 21 Protein - BP002251-PRO-677 from Syd Labs Category Protein Prices $160.00, $3,600.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

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