SPG21

Gene Symbol	SPG21
Entrez Gene	51324
Alt Symbol	ACP33, BM-019, GL010, MAST
Species	Human
Gene Type	protein-coding
Description	spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Other Description	acid cluster protein 33|maspardin
Swissprots	Q9NZD8 B4DW44 Q6ZMB6
Accessions	EAW77704 EAW77705 Q9NZD8 AA179262 AF208861 AAF64275 AF212231 AAK14917 AI161152 AK123725 AK172849 BAD18813 AK225527 AK301362 BAG62906 AK312943 BC000244 AAH00244 BI258560 BI259651 BI552731 BI554234 BI771887 BP268459 BP268875 BX446863 DA680695 DB477175 HQ447370 ADQ31856 XM_005254436 XP_005254493 XM_005254437 XP_005254494 XM_006720564 XP_006720627 XM_011521662 XP_011519964 NM_001127889 NP_001121361 NM_001127890 NP_001121362 NM_016630 NP_057714
Function	May play a role as a negative regulatory factor in CD4- dependent T-cell activation. {ECO:0000269|PubMed:11113139}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:11113139}. Membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Endosome membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans- Golgi network.
Tissue Specificity	Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level). {ECO:0000269|PubMed:11113139}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Acid cluster protein 33 Gene - orb91101 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-SPG21-cDNA-Clone - DC00099 from Abgent, a WuXi AppTec company Prices $415.80 Sizes 10 µg Species Human Accession BC000244

SPG21 - MBS1275038 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC000244

Human SPG21 cDNA clone(NM_016630.3) - CDFG000622 from Creative Biomart Species Human Accession NM_016630.3

Human SPG21 cDNA clone(NM_001127889.1) - CDFH018481 from Creative Biomart Species Human Accession NM_001127889.1

Human SPG21 cDNA clone(NM_001127890.1) - CDFH018482 from Creative Biomart Species Human Accession NM_001127890.1

Human SPG21 ORF clone(NM_016630.3) - CDCL186274 from Creative Biomart Species Human Accession NM_016630.3

Human SPG21 ORF Clone(NM_016630.3) - CDCL176834 from Creative Biomart Species Human Accession NM_016630.3

human SPG21 ORF clone - CDCH085228 from Creative Biomart Species Human Accession NM_001127889

human SPG21 ORF clone - CDCH085229 from Creative Biomart Species Human Accession NM_001127889

human SPG21 ORF clone - CDCH085230 from Creative Biomart Species Human Accession NM_001127889

human SPG21 ORF clone - CDCH085231 from Creative Biomart Species Human Accession NM_001127889

Human SPG21 ORF Clone(NM_016630.3) - CDCR300959 from Creative Biomart Species Human Accession NM_016630.3

Human SPG21 ORF Clone(NM_016630.3) - CDCR300960 from Creative Biomart Species Human Accession NM_016630.3

Human SPG21 ORF Clone(NM_016630.3) - CDCR300961 from Creative Biomart Species Human Accession NM_016630.3

Human SPG21 ORF Clone(NM_001127889.1) - CDCR348905 from Creative Biomart Species Human Accession NM_001127889.1

Human SPG21 ORF Clone(NM_001127889.1) - CDCR348906 from Creative Biomart Species Human Accession NM_001127889.1

Human SPG21 ORF Clone(NM_001127890.1) - CDCR348907 from Creative Biomart Species Human Accession NM_001127890.1

Human SPG21 ORF Clone(NM_001127890.1) - CDCR348908 from Creative Biomart Species Human Accession NM_001127890.1

Human SPG21 transcript variant 1 Gene ORF cDNA clone in cloning vector - HG10522-M from Sino Biological Species Human

Human SPG21 transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10522-UT from Sino Biological Species Human

Human SPG21 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10522-M-F from Sino Biological Species Human

Human SPG21 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10522-NH from Sino Biological Species Human

Human SPG21 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10522-ACG from Sino Biological Species Human

Human SPG21 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10522-NF from Sino Biological Species Human

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