SPG21

Gene Symbol SPG21
Entrez Gene 51324
Alt Symbol ACP33, BM-019, GL010, MAST
Species Human
Gene Type protein-coding
Description spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Other Description acid cluster protein 33|maspardin
Swissprots Q9NZD8 B4DW44 Q6ZMB6
Accessions EAW77704 EAW77705 Q9NZD8 AA179262 AF208861 AAF64275 AF212231 AAK14917 AI161152 AK123725 AK172849 BAD18813 AK225527 AK301362 BAG62906 AK312943 BC000244 AAH00244 BI258560 BI259651 BI552731 BI554234 BI771887 BP268459 BP268875 BX446863 DA680695 DB477175 HQ447370 ADQ31856 XM_005254436 XP_005254493 XM_005254437 XP_005254494 XM_006720564 XP_006720627 XM_011521662 XP_011519964 NM_001127889 NP_001121361 NM_001127890 NP_001121362 NM_016630 NP_057714
Function May play a role as a negative regulatory factor in CD4- dependent T-cell activation. {ECO:0000269|PubMed:11113139}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:11113139}. Membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Endosome membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans- Golgi network.
Tissue Specificity Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level). {ECO:0000269|PubMed:11113139}.

Maspardin CRISPR/Cas9 KO Plasmid (h) - sc-407491 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Maspardin HDR Plasmid (h) - sc-407491-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Maspardin Double Nickase Plasmid (h) - sc-407491-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Maspardin Double Nickase Plasmid (h2) - sc-407491-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Maspardin CRISPR Activation Plasmid (h) - sc-407491-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Maspardin CRISPR Activation Plasmid (h2) - sc-407491-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Maspardin Lentiviral Activation Particles (h) - sc-407491-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Maspardin Lentiviral Activation Particles (h2) - sc-407491-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Maspardin siRNA (h) - sc-75751 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Maspardin shRNA Plasmid (h) - sc-75751-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Maspardin shRNA (h) Lentiviral Particles - sc-75751-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPG21 RNAi - H00051324-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU119481 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20463 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20463 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04718 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04718

SPG21 siRNA (Human) - CRH9700 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPG21 - MBS8228247 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SPG21 (NM_016630.3) - SHH416576 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SPG21(NM_016630.3) - SHL028278 from Creative biogene

Category siRNA
Species Reactivities Human

SPG21 shRNA Plasmid (Human) - CHH9700 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SPG21 miRNA 3'UTR clone - MiUTR1H-09832 from Creative biogene

Species Reactivities Human

SPG21 miRNA 3'UTR clone - MiUTR3H-09814 from Creative biogene

Species Reactivities Human

SPG21 miRNA 3'UTR clone - MiUTR3H-09815 from Creative biogene

Species Reactivities Human
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