NDFIP1

Gene Symbol	NDFIP1
Entrez Gene	80762
Alt Symbol	N4WBP5
Species	Human
Gene Type	protein-coding
Description	Nedd4 family interacting protein 1
Other Description	NEDD4 family-interacting protein 1|Nedd4 WW domain-binding protein 5|breast cancer-associated protein SGA-1M|putative MAPK-activating protein PM13|putative NF-kappa-B-activating protein 164|putative NFKB and MAPK-activating protein
Swissprots	Q8N2F9 B2RDB8 D3DQF0 Q9BT67 Q8N2E3 Q658T8
Accessions	EAW61888 EAW61889 Q9BT67 AA496123 AB097010 BAC77363 AB097037 BAC77390 AI929639 AK075495 BAC11652 AK075524 BAC11670 AK124884 AK315481 BAG37865 AL832993 CAH56294 AY192728 AAP13460 BC004317 AAH04317 BX411356 DA236494 HQ447371 ADQ31857 NM_030571 NP_085048
Function	Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. {ECO:0000250, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:19706893, ECO:0000269|PubMed:20534535}.
Subcellular Location	Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane {ECO:0000250}. Secreted. Note=Detected in exosomes and secreted via the exosomal pathway.
Tissue Specificity	Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung. {ECO:0000269|PubMed:11748237}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Ndfip1 (T-17) - sc-69517 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Ndfip1 (D-4) - sc-398469 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

NDFIP1 (S-17) - sc-69516 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Ndfip1 (H-42) - sc-366325 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Ndfip1 (C-18) - sc-69514 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Ndfip1 antibody - ab76337 from Abcam Host Rabbit Clonality Polyclonal

Anti-Ndfip1 antibody - ab116124 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Ndfip1 antibody - ab169094 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-NDFIP1 / N4WBP5 Antibody (aa11-30, clone N1Nterm15-32.8) - LS-C82349 from LifeSpan Bioscience Prices $380.00 Sizes 50 µl Host Hamster Clonality Monoclonal Clone N1Nterm15-32.8

Anti-NDFIP1 / N4WBP5 Antibody (aa11-30, clone N1Nterm15-32.8) - LS-C82350 from LifeSpan Bioscience Prices $450.00 Sizes 100 µl Host Hamster Clonality Monoclonal Clone N1Nterm15-32.8

Anti-NDFIP1 / N4WBP5 Antibody (aa77-106, APC) - LS-C237924 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDFIP1 / N4WBP5 Antibody (aa77-106, AP) - LS-C237923 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDFIP1 / N4WBP5 Antibody (aa77-106, FITC) - LS-C237926 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDFIP1 / N4WBP5 Antibody (aa77-106, PE) - LS-C237929 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDFIP1 / N4WBP5 Antibody (aa77-106, Biotin) - LS-C237925 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDFIP1 / N4WBP5 Antibody (aa76-106) - LS-C323258 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDFIP1 / N4WBP5 Antibody (aa77-106, Azide-free, HRP) - LS-C248888 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NDFIP1 / N4WBP5 Antibody (aa77-106) - LS-C164786 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NDFIP1 / N4WBP5 Antibody (N-Terminus) IHC-plus™ - LS-B8849 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NDFIP1 / N4WBP5 Antibody (aa52-64) - LS-C87299 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

NDFIP1 Antibody - AF8246 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

NDFIP1 Antibody - NBP1-81234 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

NDFIP1 Antibody - NB100-93471 from Novus Biologicals Prices $229.00 Sizes 100 µg Host Goat Clonality Polyclonal

NDFIP1 Antibody - H00080762-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

NDFIP1 Antibody - H00080762-B01P-50ug from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

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