NDFIP1

Gene Symbol NDFIP1
Entrez Gene 80762
Alt Symbol N4WBP5
Species Human
Gene Type protein-coding
Description Nedd4 family interacting protein 1
Other Description NEDD4 family-interacting protein 1|Nedd4 WW domain-binding protein 5|breast cancer-associated protein SGA-1M|putative MAPK-activating protein PM13|putative NF-kappa-B-activating protein 164|putative NFKB and MAPK-activating protein
Swissprots Q8N2F9 B2RDB8 D3DQF0 Q9BT67 Q8N2E3 Q658T8
Accessions EAW61888 EAW61889 Q9BT67 AA496123 AB097010 BAC77363 AB097037 BAC77390 AI929639 AK075495 BAC11652 AK075524 BAC11670 AK124884 AK315481 BAG37865 AL832993 CAH56294 AY192728 AAP13460 BC004317 AAH04317 BX411356 DA236494 HQ447371 ADQ31857 NM_030571 NP_085048
Function Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. {ECO:0000250, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:19706893, ECO:0000269|PubMed:20534535}.
Subcellular Location Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane {ECO:0000250}. Secreted. Note=Detected in exosomes and secreted via the exosomal pathway.
Tissue Specificity Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung. {ECO:0000269|PubMed:11748237}.

Ndfip1 CRISPR/Cas9 KO Plasmid (h) - sc-403470 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ndfip1 HDR Plasmid (h) - sc-403470-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ndfip1 Double Nickase Plasmid (h) - sc-403470-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ndfip1 Double Nickase Plasmid (h2) - sc-403470-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ndfip1 CRISPR Activation Plasmid (h) - sc-403470-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ndfip1 CRISPR Activation Plasmid (h2) - sc-403470-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ndfip1 Lentiviral Activation Particles (h) - sc-403470-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ndfip1 Lentiviral Activation Particles (h2) - sc-403470-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ndfip1 siRNA (h) - sc-75886 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ndfip1 shRNA Plasmid (h) - sc-75886-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ndfip1 shRNA (h) Lentiviral Particles - sc-75886-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN15120 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15120 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NDFIP1 siRNA (Human) - CRJ2905 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NDFIP1 (NM_030571.3) - SHH350288 from Creative biogene

Category siRNA
Species Reactivities Human

Human NDFIP1 siRNA - orb273406 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NDFIP1 shRNA Plasmid (Human) - CHJ2905 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NDFIP1 miRNA 3'UTR clone - MiUTR4H-TG05901 from Creative biogene

Species Reactivities Human
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