NDFIP1

Gene Symbol	NDFIP1
Entrez Gene	80762
Alt Symbol	N4WBP5
Species	Human
Gene Type	protein-coding
Description	Nedd4 family interacting protein 1
Other Description	NEDD4 family-interacting protein 1|Nedd4 WW domain-binding protein 5|breast cancer-associated protein SGA-1M|putative MAPK-activating protein PM13|putative NF-kappa-B-activating protein 164|putative NFKB and MAPK-activating protein
Swissprots	Q8N2F9 B2RDB8 D3DQF0 Q9BT67 Q8N2E3 Q658T8
Accessions	EAW61888 EAW61889 Q9BT67 AA496123 AB097010 BAC77363 AB097037 BAC77390 AI929639 AK075495 BAC11652 AK075524 BAC11670 AK124884 AK315481 BAG37865 AL832993 CAH56294 AY192728 AAP13460 BC004317 AAH04317 BX411356 DA236494 HQ447371 ADQ31857 NM_030571 NP_085048
Function	Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. {ECO:0000250, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:19706893, ECO:0000269|PubMed:20534535}.
Subcellular Location	Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane {ECO:0000250}. Secreted. Note=Detected in exosomes and secreted via the exosomal pathway.
Tissue Specificity	Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung. {ECO:0000269|PubMed:11748237}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ndfip1 full length protein - ab153526 from Abcam Category Protein Source Wheat germ Species Human

Human Ndfip1 protein fragment - ab174406 from Abcam Category Protein Source E. coli Species Human

NDFIP1 / N4WBP5 Antibody Blocking Peptide - LS-E2434 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NDFIP1 / N4WBP5 Antibody Blocking Peptide - LS-E31313 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NDFIP1 / N4WBP5 Antibody Blocking Peptide - LS-E26755 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NDFIP1 Recombinant Protein - H00080762-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human NDFIP1 Protein - NBP2-23274 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

NDFIP1-Antibody-Center-Blocking-peptide - BP13449c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NDFIP1 blocking peptide - GTX88706-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

NDFIP1 protein (His tag) - 80R-3601 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

NDFIP1 Peptide - AC21-1591-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NDFIP1 (1-116, His-tag) - AR51288PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

NDFIP1 (1-116, His-tag) - AR51288PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

NDFIP1 - H00080762-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

NDFIP1 (N-term) Control Peptide - AP55498CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

NDFIP1, 1-116aa, Human, His tag, E.coli - 01-P2468 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

NDFIP1 Peptide - 46-872P from ProSci Category Peptide

NDFIP1 Peptide - 6977P from ProSci Category Peptide Species Human

NDFIP1 fusion protein - Ag14629 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

NDFIP1 fusion protein - Ag7985 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant human NDFIP1, His-tagged - NDFIP1-2468H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human NDFIP1, His-tagged - NDFIP1-1219H from Creative Biomart Category Protein Source E.coli Species Human

NDFIP1, 1-116aa, Human, His tag, E.coli - ATGP2468 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

NDFIP1, Peptide - MBS426405 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

NDFIP1 Recombinant Protein Antigen - NBP1-81234PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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