| Gene Symbol |
NDFIP1
|
| Entrez Gene |
80762
|
| Alt Symbol |
N4WBP5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Nedd4 family interacting protein 1
|
| Other Description |
NEDD4 family-interacting protein 1|Nedd4 WW domain-binding protein 5|breast cancer-associated protein SGA-1M|putative MAPK-activating protein PM13|putative NF-kappa-B-activating protein 164|putative NFKB and MAPK-activating protein
|
| Swissprots |
Q8N2F9 B2RDB8 D3DQF0 Q9BT67 Q8N2E3 Q658T8
|
| Accessions |
EAW61888 EAW61889 Q9BT67 AA496123 AB097010 BAC77363 AB097037 BAC77390 AI929639 AK075495 BAC11652 AK075524 BAC11670 AK124884 AK315481 BAG37865 AL832993 CAH56294 AY192728 AAP13460 BC004317 AAH04317 BX411356 DA236494 HQ447371 ADQ31857 NM_030571 NP_085048
|
| Function |
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. {ECO:0000250, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:19706893, ECO:0000269|PubMed:20534535}.
|
| Subcellular Location |
Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane {ECO:0000250}. Secreted. Note=Detected in exosomes and secreted via the exosomal pathway.
|
| Tissue Specificity |
Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung. {ECO:0000269|PubMed:11748237}.
|