| Gene Symbol |
TIMM50
|
| Entrez Gene |
92609
|
| Alt Symbol |
TIM50, TIM50L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
|
| Other Description |
Tim50-like protein|homolog of yeast Tim50|mitochondrial import inner membrane translocase subunit TIM50
|
| Swissprots |
Q9H370 Q96FJ5 Q96GY2 Q3ZCQ8 Q330K1 Q6QA00
|
| Accessions |
EAW56901 EAW56902 EAW56903 Q3ZCQ8 AK092396 AK097291 AK098197 AY444561 AAS68537 AY551341 AAT01208 BC009072 AAH09072 BC010736 AAH10736 BC014674 BC050082 AAH50082 BC121146 AAI21147 BC121147 AAI21148 BE386959 BI856163 BQ925812 BU540967 XM_011527491 XP_011525793 NM_001001563 NP_001001563
|
| Function |
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body. {ECO:0000269|PubMed:15044455}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000269|PubMed:15044455, ECO:0000269|PubMed:16008839}; Single-pass membrane protein {ECO:0000269|PubMed:15044455, ECO:0000269|PubMed:16008839}.
|
| Tissue Specificity |
Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level). {ECO:0000269|PubMed:15044455, ECO:0000269|PubMed:16008839}.
|