| Gene Symbol |
GOLPH3
|
| Entrez Gene |
64083
|
| Alt Symbol |
GOPP1, GPP34, MIDAS, Vps74
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
golgi phosphoprotein 3 (coat-protein)
|
| Other Description |
Golgi phosphoprotein 3|coat protein GPP34|coat-protein|golgi peripheral membrane protein 1, 34 kDa|golgi protein|golgi-associated protein|mitochondrial DNA absence factor
|
| Swissprots |
Q9UIW5 Q9H4A6
|
| Accessions |
CAF86422 CCQ43682 EAX10780 EAX10781 EAX10782 Q9H4A6 AJ296152 CAC13124 AK057544 BAG51933 AK075077 BAG52061 AK075156 BAC11438 AK092604 BAG52580 AK128510 BAG54686 AK293368 BAG56882 AK301588 BAG63078 AL133078 CAB61398 BC012123 AAH12123 BC033725 AAH33725 BC063586 AAH63586 NM_022130 NP_071413
|
| Function |
Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}.
|
| Subcellular Location |
Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Cell membrane {ECO:0000250}. Endosome {ECO:0000250}. Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes. {ECO:0000305}.
|
| Tissue Specificity |
Detected in muscle fibers of patients with mitochondrial diseases; not detected in normal muscle fibers.
|
| Top Pathways |
Transcriptional misregulation in cancer
|