GOLPH3

Gene Symbol	GOLPH3
Entrez Gene	64083
Alt Symbol	GOPP1, GPP34, MIDAS, Vps74
Species	Human
Gene Type	protein-coding
Description	golgi phosphoprotein 3 (coat-protein)
Other Description	Golgi phosphoprotein 3|coat protein GPP34|coat-protein|golgi peripheral membrane protein 1, 34 kDa|golgi protein|golgi-associated protein|mitochondrial DNA absence factor
Swissprots	Q9UIW5 Q9H4A6
Accessions	CAF86422 CCQ43682 EAX10780 EAX10781 EAX10782 Q9H4A6 AJ296152 CAC13124 AK057544 BAG51933 AK075077 BAG52061 AK075156 BAC11438 AK092604 BAG52580 AK128510 BAG54686 AK293368 BAG56882 AK301588 BAG63078 AL133078 CAB61398 BC012123 AAH12123 BC033725 AAH33725 BC063586 AAH63586 NM_022130 NP_071413
Function	Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}.
Subcellular Location	Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Cell membrane {ECO:0000250}. Endosome {ECO:0000250}. Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes. {ECO:0000305}.
Tissue Specificity	Detected in muscle fibers of patients with mitochondrial diseases; not detected in normal muscle fibers.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active C4 Protease full length protein - ab134862 from Abcam Category Protein Prices $192.00 Sizes 50 µg

Active Rubella Virus capsid protein fragment - ab68543 from Abcam Category Protein Prices $192.00 Sizes 100 µg Source E. coli

GOLPH3 peptide - ab108475 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human GOLPH3 full length protein - ab112422 from Abcam Category Protein Source Wheat germ Species Human

Rubella Virus capsid full length protein - ab74574 from Abcam Category Protein Source Saccharomyces cerevisiae

Rubella Virus capsid protein fragment - ab43034 from Abcam Category Protein Source E. coli

Rubellavirus C protein fragment - ab49040 from Abcam Category Protein Source E. coli

GOLPH3 Antibody Blocking Peptide - LS-E22709 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GOLPH3 Antibody Blocking Peptide - LS-E30794 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GOLPH3 Antibody Blocking Peptide - LS-E8958 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GOLPH3 Antibody Blocking Peptide - LS-E8959 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GOLPH3 Recombinant Protein - H00064083-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GOLPH3 Blocking Peptide - NBP1-76241PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

GOLPH3-Antibody-C-term-Blocking-Peptide - BP7445b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GOLPH3-Antibody-N-term-Blocking-Peptide - BP7445a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GOLPH3 Peptide - GTX85238-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Golgi phosphoprotein 3 / GOLPH3 - H00064083-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Golgi phosphoprotein 3 / GOLPH3 - H00064083-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Golgi phosphoprotein 3 / GOLPH3 Control Peptide - AP30372CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

GOLPH3 Peptide - 5443P from ProSci Category Peptide

GOLPH3 fusion protein - ag5278 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

GOLPH3 fusion protein - Ag5443 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human GOLPH3 - GOLPH3-26785TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Golgi phosphoprotein 3(GOLPH3) - CSB-YP872494HU CSB-EP872494HU CSB-BP872494HU CSB-MP872494HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Golgi phosphoprotein 3 / GOLPH3 - TP307477 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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