| Gene Symbol |
HOOK3
|
| Entrez Gene |
84376
|
| Alt Symbol |
HK3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hook microtubule-tethering protein 3
|
| Other Description |
h-hook3|hHK3|hook homolog 3|protein Hook homolog 3
|
| Swissprots |
Q9BY13 Q8NBH0 Q86VS8 D3DSY8
|
| Accessions |
EAW63196 EAW63197 EAW63198 EAW63199 EAW63200 Q86VS8 AK055620 AK090540 BAC03473 AK309224 BC012030 BC013679 BC023658 BC048304 AAH48304 BC056146 AAH56146 BM716064 NM_032410 NP_115786
|
| Function |
Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. {ECO:0000250, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11238449}. Golgi apparatus {ECO:0000269|PubMed:11238449}. Note=Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase. {ECO:0000250}.
|
![Western Blot: HOOK3 Overexpression Lysate (Adult Normal) [NBL1-11660] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HOOK3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5999_HOOK3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11660-img0002.jpg)