| Gene Symbol | NTMT1 |
|---|---|
| Entrez Gene | 28989 |
| Alt Symbol | AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NTM1A |
| Species | Human |
| Gene Type | protein-coding |
| Description | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
| Other Description | N-terminal RCC1 methyltransferase|X-Pro-Lys N-terminal protein methyltransferase 1A|alpha N-terminal protein methyltransferase 1A|methyltransferase-like protein 11A |
| Swissprots | A8K8G7 Q9BV86 Q9UI28 Q5SZB9 A8K4J2 |
| Accessions | CAD34801 EAW87893 EAW87894 EAW87895 Q9BV86 AF110776 AAF14859 AI802417 AK290957 BAF83646 AK292332 BAF85021 AK298840 BAG60968 AK307056 AK313829 BC001396 AAH01396 BC033234 AAH33234 BE392289 BF316784 BG468453 BI083998 BM009113 BM554138 BQ636193 BQ923165 CN406947 HY058177 XM_005251939 XP_005251996 NM_001286796 NP_001273725 NM_001286797 NP_001273726 NM_001286798 NP_001273727 NM_001286799 NP_001273728 NM_001286800 NP_001273729 NM_001286801 NP_001273730 NM_001286802 NP_001273731 NM_001286803 NP_001273732 NM_014064 NP_054783 NR_104596 |
| Function | Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000269|PubMed:20481588, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352}. Note=Predominantly nuclear. |