NTMT1

Gene Symbol	NTMT1
Entrez Gene	28989
Alt Symbol	AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NTM1A
Species	Human
Gene Type	protein-coding
Description	N-terminal Xaa-Pro-Lys N-methyltransferase 1
Other Description	N-terminal RCC1 methyltransferase|X-Pro-Lys N-terminal protein methyltransferase 1A|alpha N-terminal protein methyltransferase 1A|methyltransferase-like protein 11A
Swissprots	A8K8G7 Q9BV86 Q9UI28 Q5SZB9 A8K4J2
Accessions	CAD34801 EAW87893 EAW87894 EAW87895 Q9BV86 AF110776 AAF14859 AI802417 AK290957 BAF83646 AK292332 BAF85021 AK298840 BAG60968 AK307056 AK313829 BC001396 AAH01396 BC033234 AAH33234 BE392289 BF316784 BG468453 BI083998 BM009113 BM554138 BQ636193 BQ923165 CN406947 HY058177 XM_005251939 XP_005251996 NM_001286796 NP_001273725 NM_001286797 NP_001273726 NM_001286798 NP_001273727 NM_001286799 NP_001273728 NM_001286800 NP_001273729 NM_001286801 NP_001273730 NM_001286802 NP_001273731 NM_001286803 NP_001273732 NM_014064 NP_054783 NR_104596
Function	Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000269|PubMed:20481588, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352}. Note=Predominantly nuclear.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human METTL11A full length protein - ab162200 from Abcam Category Protein Source Wheat germ Species Human

alpha-N-terminal Methyltransferase 1A/METTL11A Recombinant Protein - H00028989-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ME11A-Antibody-N-term-Blocking-Peptide - BP13172a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human METTL11A, CF - 7159-MT-020 from R&D Systems Category Protein Source E. coli-derived, Thr2-Arg223, with an N-terminal Met and 6-His tag

Human NTMT1 protein - orb244974 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

METTL11A / C9orf32 - H00028989-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

METTL11A / C9orf32 - H00028989-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

METTL11A fusion protein - Ag10967 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

METTL11A fusion protein - Ag11254 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human METTL11A, None tagged - METTL11A-2202H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human METTL11A, GST tagged - METTL11A-2203H from Creative Biomart Category Protein Source E. coli Species Human

Human METTL11A Protein (GST Tag) - 11222-H09E-20 from Sino Biological Category Protein Prices $158.00, $298.00 Sizes 20 µg, 50 µg Source E. coli Species Human

Human METTL11A Protein - 11222-HNCE-20 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 20 µg, 50 µg Source E. coli Species Human

Recombinant Human Alpha N-terminal protein methyltransferase 1A(METTL11A) - CSB-YP880111HU CSB-BP880111HU CSB-MP880111HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human N-terminal Xaa-Pro-Lys N-methyltransferase 1 - CSB-EP880111HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human METTL11A Protein, CF - 7159-MT from R&D Systems Category Protein Prices $329.00 Sizes 20 µg Source E. coli -derived Thr2-Arg223, with an N-terminal Met and 6-His tag Species Human

N-terminal Xaa-Pro-Lys N-methyltransferase1 isoform a, 1-223aa, Human, His tag, E.coli - ATGP3259 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 4 µg, 20 µg, 100 µg Species Human

Alpha N-terminal protein methyltransferase 1A(METTL11A) - MBS1448994 from MyBioSource Category Protein Prices $1,470.00, $1,470.00, $1,935.00, $1,935.00 Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

METTL11A (His-Tag) recombinant protein - GTX17341 from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E.coli

METTL11A / C9orf32 - TP300055 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

METTL11A / C9orf32 (1-223, His-tag) - AR52014PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

METTL11A / C9orf32 (1-223, His-tag) - AR52014PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

Recombinant Human METTL11A Protein - PKSH031195 from Elabscience Category Protein Source E. coli Species Human

Recombinant Human METTL11A Protein (GST tag) - PKSH031196 from Elabscience Category Protein Source E. coli Species Human

Recombinant Human NTMT1 protein, His-tagged - NTMT1-201H from Creative Biomart Category Protein Source E.coli Species Human

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