NTMT1

Gene Symbol NTMT1
Entrez Gene 28989
Alt Symbol AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NTM1A
Species Human
Gene Type protein-coding
Description N-terminal Xaa-Pro-Lys N-methyltransferase 1
Other Description N-terminal RCC1 methyltransferase|X-Pro-Lys N-terminal protein methyltransferase 1A|alpha N-terminal protein methyltransferase 1A|methyltransferase-like protein 11A
Swissprots A8K8G7 Q9BV86 Q9UI28 Q5SZB9 A8K4J2
Accessions CAD34801 EAW87893 EAW87894 EAW87895 Q9BV86 AF110776 AAF14859 AI802417 AK290957 BAF83646 AK292332 BAF85021 AK298840 BAG60968 AK307056 AK313829 BC001396 AAH01396 BC033234 AAH33234 BE392289 BF316784 BG468453 BI083998 BM009113 BM554138 BQ636193 BQ923165 CN406947 HY058177 XM_005251939 XP_005251996 NM_001286796 NP_001273725 NM_001286797 NP_001273726 NM_001286798 NP_001273727 NM_001286799 NP_001273728 NM_001286800 NP_001273729 NM_001286801 NP_001273730 NM_001286802 NP_001273731 NM_001286803 NP_001273732 NM_014064 NP_054783 NR_104596
Function Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000269|PubMed:20481588, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352}.
Subcellular Location Nucleus {ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352}. Note=Predominantly nuclear.

METTL11A CRISPR/Cas9 KO Plasmid (h) - sc-412015 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL11A HDR Plasmid (h) - sc-412015-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL11A Double Nickase Plasmid (h) - sc-412015-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL11A Double Nickase Plasmid (h2) - sc-412015-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL11A CRISPR Activation Plasmid (h) - sc-412015-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL11A CRISPR Activation Plasmid (h2) - sc-412015-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL11A Lentiviral Activation Particles (h) - sc-412015-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL11A Lentiviral Activation Particles (h2) - sc-412015-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METTL11A siRNA (h) - sc-92868 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

METTL11A shRNA Plasmid (h) - sc-92868-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

METTL11A shRNA (h) Lentiviral Particles - sc-92868-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU025561 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13226 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13226 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NTMT1 siRNA (Human) - CRH9152 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human METTL11A (NM_014064.2) - SHH340647 from Creative biogene

Category siRNA
Species Reactivities Human

NTMT1 shRNA Plasmid (Human) - CHH9152 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NTMT1 miRNA 3'UTR clone - MiUTR1H-01532 from Creative biogene

Species Reactivities Human
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