ASTL

Gene Symbol	ASTL
Entrez Gene	431705
Alt Symbol	SAS1B
Species	Human
Gene Type	protein-coding
Description	astacin-like metallo-endopeptidase (M12 family)
Other Description	astacin-like metalloendopeptidase|astacin-like metalloendopeptidase (M12 family)|oocyte astacin|ovastacin|sperm acrosomal SLLP1 binding
Swissprots	Q3KNT0 Q6HA08
Accessions	EAW71389 Q6HA08 AJ537600 CAD61265 BC107126 AAI07127 BC107127 AAI07128 XM_011511205 XP_011509507 XM_011511206 XP_011509508 XM_011511207 XP_011509509 XM_011511208 XP_011509510 NM_001002036 NP_001002036
Function	Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=Secretory granules. Localizes to the peripheral cortical granules of ovulated eggs. Probably exocytosed from cortical granules during post- fertilization. Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles shortly after birth. Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization. Upon fertilization, detected in the perivitelline space (PVS). Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS) (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in some ovarian carcinomas. Not detected in normal tissues. {ECO:0000269|PubMed:15087446}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ASTL ELISA Kit (Sandwich ELISA) - LS-F8117 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.06 ng/ml Range 0.156-10 ng/ml

Human ASTL ELISA Kit - abx150762 from Abbexa Category ELISA Kit Sensitivity 0.060 ng/ml Range 0.156 ng/ml - 10 ng/ml

Astacin Like Metallo Endopeptidase (ASTL), Human, ELISA Kit - SEJ593Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.060ng/mL Range 0.156-10ng/mL

Astacin-like metalloendopeptidase (ASTL), Human, ELISA Kit - E01A1732 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Astacin Like Metallo Endopeptidase (ASTL), ELISA Kit - MBS2022542 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human ASTL is typically less than 0.060ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.156-10ng/mL

Astacin like metalloendopeptidase (ASTL), ELISA Kit - MBS7240936 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

astacin-like metallo-endopeptidase (M12 family) , ELISA Kit - MBS9320857 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Astacin-like metalloendopeptidase (ASTL), ELISA Kit - MBS7231496 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Astacin-like metalloendopeptidase (ASTL), ELISA Kit - MBS7248932 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Astacin-like metalloendopeptidase (ASTL), ELISA Kit - MBS7225399 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Astacin-like metalloendopeptidase (ASTL), ELISA Kit - MBS7212120 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Astacin-like metalloendopeptidase (ASTL), ELISA Kit - MBS7213402 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Astacin-like metalloendopeptidase (ASTL), ELISA Kit - MBS7214942 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Astacin-like metalloendopeptidase (ASTL), ELISA Kit - MBS7206750 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Astacin-like metalloendopeptidase (ASTL), ELISA Kit - MBS7217583 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Astacin-like metalloendopeptidase (ASTL), ELISA Kit - MBS7252671 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Astacin-like metalloendopeptidase (ASTL), ELISA Kit - MBS7225329 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Astacin-like metalloendopeptidase (ASTL), ELISA Kit - MBS7206387 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Astacin Like Metallo Endopeptidase (ASTL) - SEJ593Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.060ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Astacin Like Metallo Endopeptidase (ASTL) - SEJ593Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.060ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Astacin Like Metallo Endopeptidase (ASTL), Human, ELISA Kit - DL-ASTL-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human ASTL ELISA Kit - abx571321 from Abbexa Category ELISA Kit Sensitivity 0.060 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human ASTL ELISA Kit - E003863 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human ASTL is typically less than 0.060ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by addi

ASTL ELISA Kit (Human) (OKDD00137) - OKDD00137 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.06 ng/mL Range 0.156-10 ng/mL

Astacin Like Metallo Endopeptidase (ASTL), ELISA Kit - MBS453825 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.060ng/mL Range 0.156-10ng/mL

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