ASTL

Gene Symbol ASTL
Entrez Gene 431705
Alt Symbol SAS1B
Species Human
Gene Type protein-coding
Description astacin-like metallo-endopeptidase (M12 family)
Other Description astacin-like metalloendopeptidase|astacin-like metalloendopeptidase (M12 family)|oocyte astacin|ovastacin|sperm acrosomal SLLP1 binding
Swissprots Q3KNT0 Q6HA08
Accessions EAW71389 Q6HA08 AJ537600 CAD61265 BC107126 AAI07127 BC107127 AAI07128 XM_011511205 XP_011509507 XM_011511206 XP_011509508 XM_011511207 XP_011509509 XM_011511208 XP_011509510 NM_001002036 NP_001002036
Function Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=Secretory granules. Localizes to the peripheral cortical granules of ovulated eggs. Probably exocytosed from cortical granules during post- fertilization. Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles shortly after birth. Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization. Upon fertilization, detected in the perivitelline space (PVS). Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS) (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in some ovarian carcinomas. Not detected in normal tissues. {ECO:0000269|PubMed:15087446}.

ASTL fusion protein - ag17331 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

ASTL fusion protein - ag15997 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human ASTL - ASTL-910H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Astacin Like Metallo Endopeptidase (ASTL) - RPJ593Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

Recombinant Astacin Like Metallo Endopeptidase (ASTL) - RPJ593Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

Recombinant Human Astacin-like metalloendopeptidase(ASTL) - CSB-YP760708HU CSB-EP760708HU CSB-BP760708HU CSB-MP760708HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Astacin-like metalloendopeptidase, Recombinant Protein - MBS1231259 from MyBioSource

Category Protein
Prices $1,670.00, $1,670.00, $2,135.00, $2,135.00
Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

Astacin-like metalloendopeptidase (ASTL) , Recombinant Protein - MBS1360009 from MyBioSource

Category Protein
Prices $1,900.00, $1,900.00, $2,360.00, $2,360.00
Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

astacin-like metalloendopeptidase Recombinant Protein Antigen - NBP1-90683PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

ASTL Peptide, Human - M34GP01065H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Recombinant Human ASTL Protein (24-431 aa), His-Myc-tagged - ASTL-2574H from Creative Biomart

Category Protein
Source E. coli
Species Human
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