PAK3

Gene Symbol PAK3
Entrez Gene 5063
Alt Symbol CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK3
Species Human
Gene Type protein-coding
Description p21 protein (Cdc42/Rac)-activated kinase 3
Other Description PAK-3|beta-PAK|oligophrenin-3|p21 (CDKN1A)-activated kinase 3|p21-activated kinase 3|serine/threonine-protein kinase PAK 3
Swissprots Q8WWK5 Q9P0J8 B1GX78 Q5JWX1 Q7Z3Z8 Q8WX23 Q7Z2D6 Q5JWX2 A8K389 B1GX79 O75914 B1GX77 Q7Z2E4
Accessions BAC80720 BAC80721 BAC80722 BAC80723 BAC80724 BAC80725 BAC80726 BAC80727 BAC80728 BAC80729 BAC80730 BAC80731 BAC80732 BAC80733 BAC80734 BAC80735 BAC80736 BAC80737 BAC80738 BAC80739 BAC80750 BAC80751 BAC80752 BAC80753 BAC80754 BAC80755 BAC80756 BAC80757 BAC80758 BAC80759 BAC80760 BAC80761 BAC80762 BAC80763 BAC80764 BAC80765 BAC80766 BAC80767 BAC80768 BAC80769 BAC80780 BAC80781 BAC80782 BAC80783 BAC80784 BAC80785 BAC80786 BAC80787 BAC80788 BAC80789 BAC80790 BAC80791 BAC80792 BAC80793 BAC80794 BAC80795 BAC80796 BAC80797 BAC80798 BAC80799 EAX02653 EAX02654 O75914 AB102659 BAC81128 AF068864 AAC36097 AF155651 AAF67008 AI298548 AK124702 AK128022 AK290504 BAF83193 AK315284 BAG37693 AM943850 CAQ16016 AM943851 CAQ16017 AM943852 CAQ16018 BC117353 BC117355 BC143544 BC152761 AAI52762 BQ268758 DA022842 DA957724 DB563607 EF491800 XM_005262132 XP_005262189 XM_005262133 XP_005262190 XM_006724654 XP_006724717 XM_006724655 XP_006724718 XM_006724656 XP_006724719 XM_011530962 XP_011529264 XM_011530963 XP_011529265 XM_011530964 XP_011529266 XM_011530965 XP_011529267 XM_011530966 XP_011529268 XM_011530967 XP_011529269 XM_011530968 XP_011529270 XM_011530969 XP_011529271 XM_011530970 XP_011529272 XM_011530971 XP_011529273 XR_244474 NM_001128166 NP_001121638 NM_001128167 NP_001121639 NM_001128168 NP_001121640 NM_001128172 NP_001121644 NM_001128173 NP_001121645 NM_002578 NP_002569
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. {ECO:0000269|PubMed:21177870}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. {ECO:0000269|PubMed:12890786}.
Top Pathways Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway

PAK3 Antibody - 2609 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of mouse brain extract and recombinant GST-PAK3, using PAK3 Antibody.

α/β/γPAK (D-8) - sc-166174 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
&alpha/;β/γPAK (D-8): sc-166174. Western blot analysis of βPAK expression in NIH/3T3 (A) and SK-N-MC (B) whole cell lysates.

p-αPAK (Thr 423/402/421) - sc-101773 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-αPAK (Thr 423/402/421): sc-101773. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic staining.

βPAK (N-19) - sc-1871 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
βPAK (N-19): sc-1871. Western blot analysis of βPAK expression in rat brain extract (A) and HeLa (B), Jurkat (C), SK-N-MC (D), T24 (E) and U-937 (F) whole cell lysates.

Anti-PAK3 (phospho S154) antibody - ab80181 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab80181 stained PC12 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab80181, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-PAK3 antibody - ab50335 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PAK3 antibody - ab58281 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PAK3 antibody - ab196682 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PAK3 antibody (ab196682) at 1/500 dilutionLane 1 : HeLa cell extracts with synthesised peptideLane 2 : HeLa cell extracts

Anti-PAK3 antibody - ab37295 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PAK3 antibody - ab55996 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PAK3 antibody [EP797Y] - ab40808 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP797Y
Anti-PAK3 antibody [EP797Y] (ab40808) at 1/50000 dilution + fetal brain lysate at 10 µg

Anti-PAK3 Antibody (aa124-152, Biotin) - LS-C216593 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK3 Antibody (aa124-152, AP) - LS-C216594 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK3 Antibody (aa124-152, Azide-free, HRP) - LS-C216597 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK3 Antibody (aa124-152, FITC) - LS-C216596 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK3 Antibody (aa124-152, APC) - LS-C216595 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK3 Antibody (aa124-152, PE) - LS-C216600 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK3 Antibody (aa121-170) - LS-C118319 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from rat heart cells, using PAK3 (Ab-154) Antibody. The lane on the right is treated with the synthesized peptide.

Anti-PAK3 Antibody (Internal, AP) - LS-C220231 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK3 Antibody (Internal, FITC) - LS-C220234 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK3 Antibody (Internal, APC) - LS-C220233 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK3 Antibody (Internal, Biotin) - LS-C220235 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK3 Antibody (Internal, Azide-free, HRP) - LS-C220237 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK3 Antibody (aa99-148) - LS-C200461 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HeLa cells using PAK3 antibody.

Anti-PAK3 Antibody (Internal, PE) - LS-C220238 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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