PAK3
| Gene Symbol | PAK3 |
|---|---|
| Entrez Gene | 5063 |
| Alt Symbol | CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | p21 protein (Cdc42/Rac)-activated kinase 3 |
| Other Description | PAK-3|beta-PAK|oligophrenin-3|p21 (CDKN1A)-activated kinase 3|p21-activated kinase 3|serine/threonine-protein kinase PAK 3 |
| Swissprots | Q8WWK5 Q9P0J8 B1GX78 Q5JWX1 Q7Z3Z8 Q8WX23 Q7Z2D6 Q5JWX2 A8K389 B1GX79 O75914 B1GX77 Q7Z2E4 |
| Accessions | BAC80720 BAC80721 BAC80722 BAC80723 BAC80724 BAC80725 BAC80726 BAC80727 BAC80728 BAC80729 BAC80730 BAC80731 BAC80732 BAC80733 BAC80734 BAC80735 BAC80736 BAC80737 BAC80738 BAC80739 BAC80750 BAC80751 BAC80752 BAC80753 BAC80754 BAC80755 BAC80756 BAC80757 BAC80758 BAC80759 BAC80760 BAC80761 BAC80762 BAC80763 BAC80764 BAC80765 BAC80766 BAC80767 BAC80768 BAC80769 BAC80780 BAC80781 BAC80782 BAC80783 BAC80784 BAC80785 BAC80786 BAC80787 BAC80788 BAC80789 BAC80790 BAC80791 BAC80792 BAC80793 BAC80794 BAC80795 BAC80796 BAC80797 BAC80798 BAC80799 EAX02653 EAX02654 O75914 AB102659 BAC81128 AF068864 AAC36097 AF155651 AAF67008 AI298548 AK124702 AK128022 AK290504 BAF83193 AK315284 BAG37693 AM943850 CAQ16016 AM943851 CAQ16017 AM943852 CAQ16018 BC117353 BC117355 BC143544 BC152761 AAI52762 BQ268758 DA022842 DA957724 DB563607 EF491800 XM_005262132 XP_005262189 XM_005262133 XP_005262190 XM_006724654 XP_006724717 XM_006724655 XP_006724718 XM_006724656 XP_006724719 XM_011530962 XP_011529264 XM_011530963 XP_011529265 XM_011530964 XP_011529266 XM_011530965 XP_011529267 XM_011530966 XP_011529268 XM_011530967 XP_011529269 XM_011530968 XP_011529270 XM_011530969 XP_011529271 XM_011530970 XP_011529272 XM_011530971 XP_011529273 XR_244474 NM_001128166 NP_001121638 NM_001128167 NP_001121639 NM_001128168 NP_001121640 NM_001128172 NP_001121644 NM_001128173 NP_001121645 NM_002578 NP_002569 |
| Function | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. {ECO:0000269|PubMed:21177870}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. {ECO:0000269|PubMed:12890786}. |
| Top Pathways | Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway |
βPAK siRNA (h) - sc-36181 from Santa Cruz Biotechnology
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βPAK shRNA Plasmid (h) - sc-36181-SH from Santa Cruz Biotechnology
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βPAK shRNA (h) Lentiviral Particles - sc-36181-V from Santa Cruz Biotechnology
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PAK3 RNAi - H00005063-R02 from Novus Biologicals
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p21/CIP1/CDKN1A RNAi - H00001026-R01 from Novus Biologicals
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MISSION® esiRNA - EHU086841 from Sigma-Aldrich
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MISSION® siRNA - SIHK1492 from Sigma-Aldrich
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MISSION® siRNA - SIHK1491 from Sigma-Aldrich
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MISSION® siRNA - SIHK1490 from Sigma-Aldrich
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MISSION® siRNA - SIHK1489 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1352 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1352 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04197 from Sigma-Aldrich
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PAK3 siRNA (Human) - CRH3364 from Cohesion Biosciences
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shRNA set against Human PAK3 (NM_002578.3) - SHH370172 from Creative biogene
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PAK3 shRNA Plasmid (Human) - CHH3364 from Cohesion Biosciences
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PAK3 miRNA 3'UTR clone - MiUTR3H-02589 from Creative biogene
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PAK3 miRNA 3'UTR clone - MiUTR3H-02590 from Creative biogene
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PAK3 miRNA 3'UTR clone - MiUTR3H-02591 from Creative biogene
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PAK3 miRNA 3'UTR clone - MiUTR3H-02592 from Creative biogene
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PAK3 miRNA 3'UTR clone - MiUTR3H-02593 from Creative biogene
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PAK3 miRNA 3'UTR clone - MiUTR3H-02594 from Creative biogene
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