PAK3

Gene Symbol PAK3
Entrez Gene 5063
Alt Symbol CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK3
Species Human
Gene Type protein-coding
Description p21 protein (Cdc42/Rac)-activated kinase 3
Other Description PAK-3|beta-PAK|oligophrenin-3|p21 (CDKN1A)-activated kinase 3|p21-activated kinase 3|serine/threonine-protein kinase PAK 3
Swissprots Q8WWK5 Q9P0J8 B1GX78 Q5JWX1 Q7Z3Z8 Q8WX23 Q7Z2D6 Q5JWX2 A8K389 B1GX79 O75914 B1GX77 Q7Z2E4
Accessions BAC80720 BAC80721 BAC80722 BAC80723 BAC80724 BAC80725 BAC80726 BAC80727 BAC80728 BAC80729 BAC80730 BAC80731 BAC80732 BAC80733 BAC80734 BAC80735 BAC80736 BAC80737 BAC80738 BAC80739 BAC80750 BAC80751 BAC80752 BAC80753 BAC80754 BAC80755 BAC80756 BAC80757 BAC80758 BAC80759 BAC80760 BAC80761 BAC80762 BAC80763 BAC80764 BAC80765 BAC80766 BAC80767 BAC80768 BAC80769 BAC80780 BAC80781 BAC80782 BAC80783 BAC80784 BAC80785 BAC80786 BAC80787 BAC80788 BAC80789 BAC80790 BAC80791 BAC80792 BAC80793 BAC80794 BAC80795 BAC80796 BAC80797 BAC80798 BAC80799 EAX02653 EAX02654 O75914 AB102659 BAC81128 AF068864 AAC36097 AF155651 AAF67008 AI298548 AK124702 AK128022 AK290504 BAF83193 AK315284 BAG37693 AM943850 CAQ16016 AM943851 CAQ16017 AM943852 CAQ16018 BC117353 BC117355 BC143544 BC152761 AAI52762 BQ268758 DA022842 DA957724 DB563607 EF491800 XM_005262132 XP_005262189 XM_005262133 XP_005262190 XM_006724654 XP_006724717 XM_006724655 XP_006724718 XM_006724656 XP_006724719 XM_011530962 XP_011529264 XM_011530963 XP_011529265 XM_011530964 XP_011529266 XM_011530965 XP_011529267 XM_011530966 XP_011529268 XM_011530967 XP_011529269 XM_011530968 XP_011529270 XM_011530969 XP_011529271 XM_011530970 XP_011529272 XM_011530971 XP_011529273 XR_244474 NM_001128166 NP_001121638 NM_001128167 NP_001121639 NM_001128168 NP_001121640 NM_001128172 NP_001121644 NM_001128173 NP_001121645 NM_002578 NP_002569
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. {ECO:0000269|PubMed:21177870}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. {ECO:0000269|PubMed:12890786}.
Top Pathways Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway

Mouse/Human/Rat Phospho-PAK3 (Ser154) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1695 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat PAK3 ELISA Kit (Cell-Based ELISA) - LS-F2222 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Cyclin-dependent kinase inhibitor 1 (CDKN1A), Human, ELISA Kit - E01C1570 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Cyclin-dependent kinase inhibitor 1, CDKN1A, Human, ELISA Kit - E9387h from ARP American Research Products

Category ELISA Kit
Prices $736.00
Sizes 96 t

Serine/threonine-protein kinase PAK 3 (PAK3), Human, ELISA Kit - CSB-EL017407HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Cyclin Dependent Kinase Inhibitor 1A, CDKN1A, Mouse, ELISA Kit - E-EL-M0118 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Cyclin Dependent Kinase Inhibitor 1A, CDKN1A, Rat, ELISA Kit - E-EL-R0310 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 46.875
Range 78.125-5000pg/mL

PAK3 Colorimetric Cell-Based ELISA Kit - CB5531 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

PAK3 (Phospho-Ser154) Colorimetric Cell-Based ELISA Kit - CBP1764 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

p21 protein (Cdc42/Rac) -activated kinase 3, ELISA Kit - MBS923999 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 5.86 pg/ml
Range 23.44 pg/ml-1500 pg/ml

Human Serine/threonine-protein kinase PAK 3(PAK3) ELISA kit - CSB-EL017407HU from Cusabio

Category ELISA Kit
Sensitivity 5.86 pg/ml.
Range 23.44 pg/ml-1500 pg/ml

Human CDKN1A(Cyclin Dependent Kinase Inhibitor 1A) ELISA Kit - E-EL-H2473 from Elabscience

Category ELISA Kit
Sensitivity 46.88 pg/mL
Range 78.13—5000 pg/mL

PAK3 ELISA Kit - DEIA-XYA1410 from Creative Diagnostics

Category ELISA Kit

PAK3 (Phospho-Ser154) ELISA Kit - DEIA-XYA1411 from Creative Diagnostics

Category ELISA Kit

Human CDKN1A ELISA Kit - E010678 from Biobool

Category ELISA Kit
Sensitivity 7.81 pg/ml

Human PAK3 ELISA Kit - E028064 from Biobool

Category ELISA Kit
Sensitivity 5.86 pg/ml

PAK3 ELISA Kit (Human) (OKCA01510) - OKCA01510 from Aviva Systems Biology

Category ELISA Kit
Prices $600.00
Sizes 96 wells
Sensitivity 5.86 pg/mL
Range 23.44 - 1,500 pg/mL

Human CDKN1A(Cyclin Dependent Kinase Inhibitor 1A) ELISA Kit - E-EL-H2473 from Iwai North America Inc.

Category ELISA Kit
Prices $580.00
Sizes 1 kit
Sensitivity 46.88 pg/mLpg/mL
Range 78.13~5000 pg/mL

Human Serine/threonine-protein kinase PAK 3 (PAK3) ELISA Kit - AE28753HU from ARP American Research Products

Category ELISA Kit
Prices $549.00
Sizes 96 t
Sensitivity 5.86 pg/mL
Range 23.44-1500 pg/mL

PAK3 Colorimetric Cell-Based ELISA Kit - EKA50457 from Biomatik

Category ELISA Kit
Prices $399.00
Sizes 96 tests
Sensitivity At least 5000 cells/well
Range Qualitative
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