PAK3

Gene Symbol	PAK3
Entrez Gene	5063
Alt Symbol	CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK3
Species	Human
Gene Type	protein-coding
Description	p21 protein (Cdc42/Rac)-activated kinase 3
Other Description	PAK-3|beta-PAK|oligophrenin-3|p21 (CDKN1A)-activated kinase 3|p21-activated kinase 3|serine/threonine-protein kinase PAK 3
Swissprots	Q8WWK5 Q9P0J8 B1GX78 Q5JWX1 Q7Z3Z8 Q8WX23 Q7Z2D6 Q5JWX2 A8K389 B1GX79 O75914 B1GX77 Q7Z2E4
Accessions	BAC80720 BAC80721 BAC80722 BAC80723 BAC80724 BAC80725 BAC80726 BAC80727 BAC80728 BAC80729 BAC80730 BAC80731 BAC80732 BAC80733 BAC80734 BAC80735 BAC80736 BAC80737 BAC80738 BAC80739 BAC80750 BAC80751 BAC80752 BAC80753 BAC80754 BAC80755 BAC80756 BAC80757 BAC80758 BAC80759 BAC80760 BAC80761 BAC80762 BAC80763 BAC80764 BAC80765 BAC80766 BAC80767 BAC80768 BAC80769 BAC80780 BAC80781 BAC80782 BAC80783 BAC80784 BAC80785 BAC80786 BAC80787 BAC80788 BAC80789 BAC80790 BAC80791 BAC80792 BAC80793 BAC80794 BAC80795 BAC80796 BAC80797 BAC80798 BAC80799 EAX02653 EAX02654 O75914 AB102659 BAC81128 AF068864 AAC36097 AF155651 AAF67008 AI298548 AK124702 AK128022 AK290504 BAF83193 AK315284 BAG37693 AM943850 CAQ16016 AM943851 CAQ16017 AM943852 CAQ16018 BC117353 BC117355 BC143544 BC152761 AAI52762 BQ268758 DA022842 DA957724 DB563607 EF491800 XM_005262132 XP_005262189 XM_005262133 XP_005262190 XM_006724654 XP_006724717 XM_006724655 XP_006724718 XM_006724656 XP_006724719 XM_011530962 XP_011529264 XM_011530963 XP_011529265 XM_011530964 XP_011529266 XM_011530965 XP_011529267 XM_011530966 XP_011529268 XM_011530967 XP_011529269 XM_011530968 XP_011529270 XM_011530969 XP_011529271 XM_011530970 XP_011529272 XM_011530971 XP_011529273 XR_244474 NM_001128166 NP_001121638 NM_001128167 NP_001121639 NM_001128168 NP_001121640 NM_001128172 NP_001121644 NM_001128173 NP_001121645 NM_002578 NP_002569
Function	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. {ECO:0000269|PubMed:21177870}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. {ECO:0000269|PubMed:12890786}.
Top Pathways	Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PAK3 protein fragment - ab159049 from Abcam Category Protein Source Wheat germ Species Human

CDKN1A / WAF1 / p21 Antibody Blocking Peptide - LS-E2447 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1A / WAF1 / p21 Antibody Blocking Peptide - LS-E7293 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1A / WAF1 / p21 Antibody Blocking Peptide - LS-E7295 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1A / WAF1 / p21 Antibody Blocking Peptide - LS-E7294 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1A / WAF1 / p21 Antibody Blocking Peptide - LS-E9026 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1A / WAF1 / p21 Antibody Blocking Peptide - LS-E10059 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAK3 Antibody Blocking Peptide - LS-E2821 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAK3 Antibody Blocking Peptide - LS-E9374 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human p21/CIP1/CDKN1A Protein - H00001026-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

p21/CIP1/CDKN1A Partial Recombinant Protein - H00001026-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human p21/CIP1/CDKN1A Protein - H00001026-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PAK3 Protein - H00005063-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

p21/CIP1/CDKN1A Protein - NBP2-22976 from Novus Biologicals Category Protein Species Human

PAK3 Recombinant Protein - P4742 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

p21/CIP1/CDKN1A Peptide - P1372 from Novus Biologicals Category Peptide Species Human

p21/CIP1/CDKN1A Peptide - P1371 from Novus Biologicals Category Peptide Species Human

p21/CIP1/CDKN1A Peptide - P1370 from Novus Biologicals Category Peptide Species Human

p21/CIP1/CDKN1A Peptide - P1369 from Novus Biologicals Category Peptide Species Human

p21/CIP1/CDKN1A Peptide - P2533 from Novus Biologicals Category Peptide Species Human

PAK3-Antibody-C-term-Blocking-Peptide - BP7928d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAK3-Antibody-Center-K218-Blocking-Peptide - BP7928a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CDKN1A protein - orb168092 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Species Human

Human PAK3 His tag protein - orb84774 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Insect Species Human

PAK3 peptide - orb217713 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse

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