| Gene Symbol |
ATXN1L
|
| Entrez Gene |
342371
|
| Alt Symbol |
BOAT, BOAT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ataxin 1-like
|
| Other Description |
ataxin-1-like|brother of ATXN1|brother of ataxin-1
|
| Swissprots |
P0C7T5
|
| Accessions |
EAW59221 P0C7T5 AB621810 BAK64146 AI720164 AK025113 AK025339 AL833385 BC042985 BX537575 BX537596 DB097328 NR_024612 NM_001137675 NP_001131147
|
| Function |
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16121196}. Cell projection, dendrite {ECO:0000269|PubMed:16121196}. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
|
| Tissue Specificity |
Expressed in cerebellum and cerebral cortex. {ECO:0000269|PubMed:16121196}.
|