Gene Symbol | ATXN1L |
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Entrez Gene | 342371 |
Alt Symbol | BOAT, BOAT1 |
Species | Human |
Gene Type | protein-coding |
Description | ataxin 1-like |
Other Description | ataxin-1-like|brother of ATXN1|brother of ataxin-1 |
Swissprots | P0C7T5 |
Accessions | EAW59221 P0C7T5 AB621810 BAK64146 AI720164 AK025113 AK025339 AL833385 BC042985 BX537575 BX537596 DB097328 NR_024612 NM_001137675 NP_001131147 |
Function | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:16121196}. Cell projection, dendrite {ECO:0000269|PubMed:16121196}. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells. |
Tissue Specificity | Expressed in cerebellum and cerebral cortex. {ECO:0000269|PubMed:16121196}. |
ATXN1L Antibody Blocking Peptide - LS-E6145 from LifeSpan Bioscience
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ATXN1L-Antibody-Center-Blocking-Peptide - BP18768c from Abgent, a WuXi AppTec company
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Recombinant Human ATXN1L, His-tagged - ATXN1L-3685H from Creative Biomart
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Recombinant Human ATXN1L - ATXN1L-1220H from Creative Biomart
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Recombinant Human Ataxin-1-like(ATXN1L) - CSB-YP002440HU CSB-EP002440HU CSB-BP002440HU CSB-MP002440HU from Cusabio
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Ataxin-1-like (ATXN1L) , Recombinant Protein - MBS718671 from MyBioSource
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ATXN1L Peptide, Human - M34GP01218H from Creative Peptides
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ATXN1L Recombinant Protein Antigen - NBP2-56746PEP from Novus Biologicals
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ATXN1L Recombinant Protein Antigen - NBP2-57478PEP from Novus Biologicals
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