| Gene Symbol |
ANAPC2
|
| Entrez Gene |
29882
|
| Alt Symbol |
APC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
anaphase promoting complex subunit 2
|
| Other Description |
anaphase-promoting complex subunit 2|cyclosome subunit 2
|
| Swissprots |
Q96GG4 Q9UJX6 Q9P2E1 Q96DG5 Q5VSG1
|
| Accessions |
EAW88361 Q9UJX6 AB037827 BAA92644 AF191337 AAF05751 AK294601 BAG57788 AK296204 BAG58931 BC001579 AAH01579 BC009487 AAH09487 BC032503 AAH32503 BC033579 BM925063 BU526961 DQ890852 ABM81778 DQ894007 ABM84933 XR_929779 XR_929780 XR_929781 NM_013366 NP_037498
|
| Function |
Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873}.
|
| Top Pathways |
Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection
|