ANAPC2

Gene Symbol	ANAPC2
Entrez Gene	29882
Alt Symbol	APC2
Species	Human
Gene Type	protein-coding
Description	anaphase promoting complex subunit 2
Other Description	anaphase-promoting complex subunit 2|cyclosome subunit 2
Swissprots	Q96GG4 Q9UJX6 Q9P2E1 Q96DG5 Q5VSG1
Accessions	EAW88361 Q9UJX6 AB037827 BAA92644 AF191337 AAF05751 AK294601 BAG57788 AK296204 BAG58931 BC001579 AAH01579 BC009487 AAH09487 BC032503 AAH32503 BC033579 BM925063 BU526961 DQ890852 ABM81778 DQ894007 ABM84933 XR_929779 XR_929780 XR_929781 NM_013366 NP_037498
Function	Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873}.
Top Pathways	Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® APC2 siRNA I - 11866 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

ANAPC2 CRISPR/Cas9 KO Plasmid (h) - sc-404962 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ANAPC2 HDR Plasmid (h) - sc-404962-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ANAPC2 Double Nickase Plasmid (h) - sc-404962-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ANAPC2 Double Nickase Plasmid (h2) - sc-404962-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ANAPC2 CRISPR Activation Plasmid (h) - sc-404962-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ANAPC2 CRISPR Activation Plasmid (h2) - sc-404962-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ANAPC2 Lentiviral Activation Particles (h) - sc-404962-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ANAPC2 Lentiviral Activation Particles (h2) - sc-404962-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ANAPC2 siRNA (h) - sc-77332 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ANAPC2 shRNA Plasmid (h) - sc-77332-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ANAPC2 shRNA (h) Lentiviral Particles - sc-77332-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ANAPC2 RNAi - H00029882-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

ANAPC2 RNAi - H00029882-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU017101 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3140 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3140 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

ANAPC2 siRNA (Human) - CRH9245 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ANAPC2 - MBS8209096 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ANAPC2 (NM_013366.3) - SHH236118 from Creative biogene Category siRNA Species Reactivities Human

Human ANAPC2 siRNA - orb269747 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ANAPC2 shRNA Plasmid (Human) - CHH9245 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ANAPC2 miRNA 3'UTR clone - MiUTR1H-00356 from Creative biogene Species Reactivities Human

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