ANAPC2

Gene Symbol	ANAPC2
Entrez Gene	29882
Alt Symbol	APC2
Species	Human
Gene Type	protein-coding
Description	anaphase promoting complex subunit 2
Other Description	anaphase-promoting complex subunit 2|cyclosome subunit 2
Swissprots	Q96GG4 Q9UJX6 Q9P2E1 Q96DG5 Q5VSG1
Accessions	EAW88361 Q9UJX6 AB037827 BAA92644 AF191337 AAF05751 AK294601 BAG57788 AK296204 BAG58931 BC001579 AAH01579 BC009487 AAH09487 BC032503 AAH32503 BC033579 BM925063 BU526961 DQ890852 ABM81778 DQ894007 ABM84933 XR_929779 XR_929780 XR_929781 NM_013366 NP_037498
Function	Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873}.
Top Pathways	Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human APC2 peptide - ab88193 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human Apc2 protein fragment - ab127267 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

Human Apolipoprotein CII full length protein - ab77878 from Abcam Category Protein Prices $356.00 Sizes 50 µg Source Native Species Human

Human Apolipoprotein CII full length protein - ab90925 from Abcam Category Protein Prices $356.00 Sizes 50 µg Source Native Species Human

Human Apolipoprotein CII peptide - ab88220 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Recombinant Human ANAPC2 Protein - H00029882-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ANAPC2 Recombinant Protein - H00029882-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 10 ug 25 ug Species Human

Apc2 Blocking Peptide - NBP1-77376PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

ANAPC2 Protein Lysate (APL11043) - APL11043 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

ANAPC2 Protein Lysate (APL11044) - APL11044 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

APC2 Blocking Peptide - 33R-4804 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

APC2 / ANAPC2 - H00029882-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

APC2 / ANAPC2 - H00029882-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ANAPC2 fusion protein - ag4427 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ANAPC2 fusion protein - ag16487 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Apolipoprotein C2 (APOC2) - RPB996Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Anaphase-promoting complex subunit 2(ANAPC2) ,partial - CSB-YP892446HU CSB-EP892446HU CSB-BP892446HU CSB-MP892446HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ANAPC2 Protein - abx163077 from Abbexa Category Protein Species Human

APC2 / ANAPC2 - TP307539 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Anaphase-promoting complex subunit 2(ANAPC2) ,partial, Recombinant Protein - MBS1448747 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ANAPC2 Protein Lysate - orb333619 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

ANAPC2-Blocking-Peptide-C-term - BP21055a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ANAPC2 Peptide, Human - M34GP00584H from Creative Peptides Category Peptide Source Synthetic. Species Human

APC2 Peptide, Human - M34GP00746H from Creative Peptides Category Peptide Source Synthetic. Species Human

ANAPC2 Recombinant Protein Antigen - NBP2-56603PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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