ANAPC2

Gene Symbol	ANAPC2
Entrez Gene	29882
Alt Symbol	APC2
Species	Human
Gene Type	protein-coding
Description	anaphase promoting complex subunit 2
Other Description	anaphase-promoting complex subunit 2\|cyclosome subunit 2
Swissprots	Q96GG4 Q9UJX6 Q9P2E1 Q96DG5 Q5VSG1
Accessions	EAW88361 Q9UJX6 AB037827 BAA92644 AF191337 AAF05751 AK294601 BAG57788 AK296204 BAG58931 BC001579 AAH01579 BC009487 AAH09487 BC032503 AAH32503 BC033579 BM925063 BU526961 DQ890852 ABM81778 DQ894007 ABM84933 XR_929779 XR_929780 XR_929781 NM_013366 NP_037498
Function	Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. {ECO:0000269\|PubMed:11739784, ECO:0000269\|PubMed:18485873}.
Top Pathways	Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection

APC2 Antibody - 12301 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from various cell lines using APC2 Antibody.

ANAPC2 (H-295) - sc-20984 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

ANAPC2 (H-295): sc-20984. Immunofluorescence staining of normal mouse kidney frozen section showing nuclear staining.

ANAPC2 (N-19) - sc-249924 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-Apc2 antibody - ab106600 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunofluorescence of Apc2 in HeLa cells with ab106600 at 20 ug/mL.

Anti-Apc2 antibody - ab57094 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab57094 Apc2 antibody at 1ug/ml.

Anti-Apc2 antibody [1A6] - ab123855 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1A6

All lanes : Anti-Apc2 antibody [1A6] (ab123855) at 1/500 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY Apc2 cDNALysates/proteins at 5 µg per lane.

Anti-Apc2 antibody - BSA and Azide free - ab77563 from Abcam

Prices	$370.00
Sizes	250 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Apc2 antibody - C-terminal - ab197835 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Apc2 antibody - C-terminal (ab197835) at 1/200 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLane 3 : NIH3T3 cell lysateLysates/proteins at 40 µg per lane.

Anti-ANAPC2 / APC2 Antibody (aa807-819, Azide-free) - LS-C20693 from LifeSpan Bioscience

Prices	$605.00
Sizes	500 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ANAPC2 / APC2 Antibody (C-Terminus) - LS-C182072 from LifeSpan Bioscience

Prices	$425.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ANAPC2 / APC2 Antibody - LS-C306241 from LifeSpan Bioscience

Prices	$455.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-ANAPC2 / APC2 Antibody (aa716-823) - LS-C306243 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-ANAPC2 / APC2 Antibody (aa604-820) - LS-C178650 from LifeSpan Bioscience

Prices	$255.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ANAPC2 / APC2 Antibody (clone 3E1) - LS-C173312 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3E1

Anti-ANAPC2 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ANAPC2.

Anti-ANAPC2 / APC2 Antibody (clone 2A1) - LS-C173235 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2A1

Anti-ANAPC2 / APC2 Antibody (clone 1B12) - LS-C173234 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1B12

Anti-ANAPC2 / APC2 Antibody (clone 1B11) - LS-C340596 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1B11

Anti-ANAPC2 / APC2 Antibody (clone 1H8) - LS-C173236 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1H8

Anti-ANAPC2 / APC2 Antibody (clone 1A6) - LS-C173239 from LifeSpan Bioscience

Prices	$350.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1A6

IHC of paraffin-embedded Human lymphoma tissue using anti-ANAPC2 mouse monoclonal antibody.

ANAPC2 Antibody (1A6) - NBP2-01128 from Novus Biologicals

Prices	$379.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1A6

Western Blot: ANAPC2 Antibody (1A6) [NBP2-01128] Analysis of extracts (35ug) from 9 different cell lines by using anti-ANAPC2 monoclonal antibody.

ANAPC2 Antibody - H00029882-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: ANAPC2 Antibody [H00029882-B01P] - Analysis of ANAPC2 expression in human liver.

ANAPC2 Antibody (8G2) - H00029882-M01 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	8G2

Anti-ANAPC2 (203-215) antibody produced in rabbit - A4358 from Sigma-Aldrich

Prices	$342.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Anti-ANAPC2 (203-215): <B>Cat. No. A4358</B>: Immunofluorescence of HUVEC cells using ANAPC2 (203-215) (RB),<B>Cat. No. A4358</B> (red) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Monoclonal Anti-ANAPC2 antibody produced in mouse - WH0029882M1 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	8G2

<B>Immunoblotting</B><BR/>Monoclonal Anti-ANAPC2, <B>Cat. No. WH0029882M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37.88 kDa using immunogen protein lysate.

Anti-ANAPC2 antibody produced in mouse - SAB1407387 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-ANAPC2: <B>Cat. No. SAB1407387</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~93.8 kDa using human liver lysate.

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