| Gene Symbol |
TWF2
|
| Entrez Gene |
11344
|
| Alt Symbol |
A6RP, A6r, MSTP011, PTK9L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
twinfilin actin-binding protein 2
|
| Other Description |
A6-related protein|PTK9L protein tyrosine kinase 9-like (A6-related protein)|protein tyrosine kinase 9-like (A6-related protein)|twinfilin, actin-binding protein, homolog 2|twinfilin-1-like protein|twinfilin-2
|
| Swissprots |
Q9Y3F5 Q6IBS0
|
| Accessions |
EAW65194 Q6IBS0 AF109365 AAQ13513 AL136773 CAB66707 BC000327 AAH00327 BC003161 AAH03161 BC016452 AAH16452 BI551353 CR456732 CAG33013 CR533520 CAG38551 DQ891754 ABM82680 DQ894936 ABM85862 Y17169 CAB38055 NM_007284 NP_009215
|
| Function |
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10406962}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10406962}. Cell projection, stereocilium {ECO:0000250}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization.
|
| Tissue Specificity |
Ubiquitously expressed (at protein level). {ECO:0000269|PubMed:10406962}.
|
![Western Blot: TWF2 Overexpression Lysate (Adult Normal) [NBL1-17459] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TWF2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3436_TWF2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17459-img0002.jpg)