Gene Symbol | TWF2 |
---|---|
Entrez Gene | 11344 |
Alt Symbol | A6RP, A6r, MSTP011, PTK9L |
Species | Human |
Gene Type | protein-coding |
Description | twinfilin actin-binding protein 2 |
Other Description | A6-related protein|PTK9L protein tyrosine kinase 9-like (A6-related protein)|protein tyrosine kinase 9-like (A6-related protein)|twinfilin, actin-binding protein, homolog 2|twinfilin-1-like protein|twinfilin-2 |
Swissprots | Q9Y3F5 Q6IBS0 |
Accessions | EAW65194 Q6IBS0 AF109365 AAQ13513 AL136773 CAB66707 BC000327 AAH00327 BC003161 AAH03161 BC016452 AAH16452 BI551353 CR456732 CAG33013 CR533520 CAG38551 DQ891754 ABM82680 DQ894936 ABM85862 Y17169 CAB38055 NM_007284 NP_009215 |
Function | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10406962}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10406962}. Cell projection, stereocilium {ECO:0000250}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. |
Tissue Specificity | Ubiquitously expressed (at protein level). {ECO:0000269|PubMed:10406962}. |