| Gene Symbol |
MKRN1
|
| Entrez Gene |
23608
|
| Alt Symbol |
RNF61
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
makorin ring finger protein 1
|
| Other Description |
E3 ubiquitin-protein ligase makorin-1|RING finger protein 61
|
| Swissprots |
Q9UEZ7 Q59G11 Q9UHC7 Q6GSF1 A4D1T7 B3KXB4 Q256Y7 Q9H0G0 Q9UHW2
|
| Accessions |
AAF18979 EAL24026 EAW83949 EAW83950 EAW83951 EAW83952 EAW83953 Q9UHC7 AB209298 BAD92535 AF117233 AAF17214 AF192784 AAF17487 AI828363 AK024987 AK027137 AK127030 BAG54426 AK297361 BAG59808 AK315552 BAG37929 AL136812 CAB66746 AM236048 CAJ84705 BC012398 BC025955 AAH25955 BC037400 AAH37400 BC051821 BC064838 AAH64838 BC127216 AAI27217 CA438497 DC400746 DQ892404 ABM83330 EU176516 ABW03317 XM_011515996 XP_011514298 XM_011515997 XP_011514299 XM_011515998 XP_011514300 NM_001145125 NP_001138597 NM_001291663 NP_001278592 NM_013446 NP_038474 NR_117084
|
| Function |
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10843807, ECO:0000269|PubMed:16785614}.
|
![Western Blot: MKRN1 Overexpression Lysate (Adult Normal) [NBL1-13126] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MKRN1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1479_MKRN1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13126-img0002.jpg)