MKRN1

Gene Symbol MKRN1
Entrez Gene 23608
Alt Symbol RNF61
Species Human
Gene Type protein-coding
Description makorin ring finger protein 1
Other Description E3 ubiquitin-protein ligase makorin-1|RING finger protein 61
Swissprots Q9UEZ7 Q59G11 Q9UHC7 Q6GSF1 A4D1T7 B3KXB4 Q256Y7 Q9H0G0 Q9UHW2
Accessions AAF18979 EAL24026 EAW83949 EAW83950 EAW83951 EAW83952 EAW83953 Q9UHC7 AB209298 BAD92535 AF117233 AAF17214 AF192784 AAF17487 AI828363 AK024987 AK027137 AK127030 BAG54426 AK297361 BAG59808 AK315552 BAG37929 AL136812 CAB66746 AM236048 CAJ84705 BC012398 BC025955 AAH25955 BC037400 AAH37400 BC051821 BC064838 AAH64838 BC127216 AAI27217 CA438497 DC400746 DQ892404 ABM83330 EU176516 ABW03317 XM_011515996 XP_011514298 XM_011515997 XP_011514299 XM_011515998 XP_011514300 NM_001145125 NP_001138597 NM_001291663 NP_001278592 NM_013446 NP_038474 NR_117084
Function E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10843807, ECO:0000269|PubMed:16785614}.

Makorin-1 CRISPR/Cas9 KO Plasmid (h) - sc-418248 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Makorin-1 HDR Plasmid (h) - sc-418248-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Makorin-1 Double Nickase Plasmid (h) - sc-418248-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Makorin-1 Double Nickase Plasmid (h2) - sc-418248-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Makorin-1 CRISPR Activation Plasmid (h) - sc-418248-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Makorin-1 CRISPR Activation Plasmid (h2) - sc-418248-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Makorin-1 Lentiviral Activation Particles (h) - sc-418248-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Makorin-1 Lentiviral Activation Particles (h2) - sc-418248-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Makorin-1 siRNA (h) - sc-62584 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Makorin-1 shRNA Plasmid (h) - sc-62584-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Makorin-1 shRNA (h) Lentiviral Particles - sc-62584-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MKRN1 RNAi - H00023608-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU105651 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14383 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14383 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MKRN1 siRNA (Human) - CRH8394 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MKRN1 (NM_013446.3) - SHH342328 from Creative biogene

Category siRNA
Species Reactivities Human

Human MKRN1 siRNA - orb268896 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MKRN1 shRNA Plasmid (Human) - CHH8394 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MKRN1 miRNA 3'UTR clone - MiUTR3H-09443 from Creative biogene

Species Reactivities Human

MKRN1 miRNA 3'UTR clone - MiUTR3H-09444 from Creative biogene

Species Reactivities Human
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