| Gene Symbol |
OTUD5
|
| Entrez Gene |
55593
|
| Alt Symbol |
DUBA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
OTU deubiquitinase 5
|
| Other Description |
OTU domain containing 5|OTU domain-containing protein 5|deubiquinating enzyme A|deubiquitinating enzyme A
|
| Swissprots |
B4DGG7 Q4KMN9 G5E9D7 Q9H650 Q96G74 Q9NT65 Q9H9U0 Q8N6T5
|
| Accessions |
EAW50722 EAW50723 EAW50724 EAW50725 EAW50726 EAW50727 Q96G74 AK022612 BAB14131 AK026260 BAB15416 AK294590 BAG57778 AL137509 CAB70778 BC009917 AAH09917 BC011738 BC028225 AAH28225 BC098440 AAH98440 BM797460 BY799160 CB243128 CN368451 DA237046 DC419901 XM_005272622 XP_005272679 XM_005278039 XP_005278096 XM_005278042 XP_005278099 XM_006724537 XP_006724600 XM_011543932 XP_011542234 XM_011543933 XP_011542235 XM_011543934 XP_011542236 NM_001136157 NP_001129629 NM_001136158 NP_001129630 NM_001136159 NP_001129631 NM_017602 NP_060072
|
| Function |
Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681}.
|
| Tissue Specificity |
Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. {ECO:0000269|PubMed:17991829}.
|
| Top Pathways |
RIG-I-like receptor signaling pathway
|