Gene Symbol | OTUD5 |
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Entrez Gene | 55593 |
Alt Symbol | DUBA |
Species | Human |
Gene Type | protein-coding |
Description | OTU deubiquitinase 5 |
Other Description | OTU domain containing 5|OTU domain-containing protein 5|deubiquinating enzyme A|deubiquitinating enzyme A |
Swissprots | B4DGG7 Q4KMN9 G5E9D7 Q9H650 Q96G74 Q9NT65 Q9H9U0 Q8N6T5 |
Accessions | EAW50722 EAW50723 EAW50724 EAW50725 EAW50726 EAW50727 Q96G74 AK022612 BAB14131 AK026260 BAB15416 AK294590 BAG57778 AL137509 CAB70778 BC009917 AAH09917 BC011738 BC028225 AAH28225 BC098440 AAH98440 BM797460 BY799160 CB243128 CN368451 DA237046 DC419901 XM_005272622 XP_005272679 XM_005278039 XP_005278096 XM_005278042 XP_005278099 XM_006724537 XP_006724600 XM_011543932 XP_011542234 XM_011543933 XP_011542235 XM_011543934 XP_011542236 NM_001136157 NP_001129629 NM_001136158 NP_001129630 NM_001136159 NP_001129631 NM_017602 NP_060072 |
Function | Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681}. |
Tissue Specificity | Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. {ECO:0000269|PubMed:17991829}. |
Top Pathways | RIG-I-like receptor signaling pathway |
Human OTUD5 full length protein - ab163135 from Abcam
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OTUD5 Antibody Blocking Peptide - LS-E26775 from LifeSpan Bioscience
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OTUD5 Antibody Blocking Peptide - LS-E30577 from LifeSpan Bioscience
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Recombinant Human OTUD5 Protein - H00055593-P01 from Novus Biologicals
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OTUD5 Blocking Peptide - NBP1-76943PEP from Novus Biologicals
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DUBA blocking peptide - GTX88701-PEP from GeneTex
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OTUD5 Peptide - AC21-1608-P from Abcore
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OTUD5 - H00055593-P01-10 from Acris Antibodies
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OTUD5 - H00055593-P01-25 from Acris Antibodies
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OTUD5 control peptide - AP26191CP-N from Acris Antibodies
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DUBA Peptide - 46-833P from ProSci
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OTUD5 Peptide - 4811P from ProSci
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OTUD5 fusion protein - Ag15628 from Proteintech Group
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OTUD5 fusion protein - ag15190 from Proteintech Group
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Recombinant Human OTUD5, His-tagged - OTUD5-1480H from Creative Biomart
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Recombinant Human OTUD5, GST-tagged - OTUD5-165H from Creative Biomart
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Recombinant Human OTU domain-containing protein 5(OTUD5) - CSB-YP850298HU CSB-EP850298HU CSB-BP850298HU CSB-MP850298HU from Cusabio
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OTUD5 (transcript variant 1) - TP300893 from Acris Antibodies
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DUBA, Peptide - MBS426397 from MyBioSource
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OTUD5 Recombinant Protein Antigen - NBP1-85044PEP from Novus Biologicals
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OTUD5 Peptide, Human - M34GP11171H from Creative Peptides
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OTU domain-containing protein 5 (OTUD5), Recombinant Protein - MBS1383650 from MyBioSource
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OTUD5 Immunizing peptide - orb55092 from Biorbyt
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Recombinant Human OTUD5 Protein, MYC/DDK-tagged - OTUD5-373H from Creative Biomart
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