OTUD5

Gene Symbol OTUD5
Entrez Gene 55593
Alt Symbol DUBA
Species Human
Gene Type protein-coding
Description OTU deubiquitinase 5
Other Description OTU domain containing 5|OTU domain-containing protein 5|deubiquinating enzyme A|deubiquitinating enzyme A
Swissprots B4DGG7 Q4KMN9 G5E9D7 Q9H650 Q96G74 Q9NT65 Q9H9U0 Q8N6T5
Accessions EAW50722 EAW50723 EAW50724 EAW50725 EAW50726 EAW50727 Q96G74 AK022612 BAB14131 AK026260 BAB15416 AK294590 BAG57778 AL137509 CAB70778 BC009917 AAH09917 BC011738 BC028225 AAH28225 BC098440 AAH98440 BM797460 BY799160 CB243128 CN368451 DA237046 DC419901 XM_005272622 XP_005272679 XM_005278039 XP_005278096 XM_005278042 XP_005278099 XM_006724537 XP_006724600 XM_011543932 XP_011542234 XM_011543933 XP_011542235 XM_011543934 XP_011542236 NM_001136157 NP_001129629 NM_001136158 NP_001129630 NM_001136159 NP_001129631 NM_017602 NP_060072
Function Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681}.
Tissue Specificity Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. {ECO:0000269|PubMed:17991829}.
Top Pathways RIG-I-like receptor signaling pathway

Human OTUD5 cDNA clone(NM_001136157.1) - CDFH013527 from Creative Biomart

Species Human
Accession NM_001136157.1

Human OTUD5 cDNA clone(NM_001136158.1) - CDFH013528 from Creative Biomart

Species Human
Accession NM_001136158.1

Human OTUD5 cDNA clone(NM_001136159.1) - CDFH013529 from Creative Biomart

Species Human
Accession NM_001136159.1

Human OTUD5 ORF clone(NM_017602.3) - CDCH394795 from Creative Biomart

Species Human
Accession NM_017602.3

Human OTUD5 ORF Clone(NM_001136157.1) - CDCR350787 from Creative Biomart

Species Human
Accession NM_001136157.1

Human OTUD5 ORF Clone(NM_001136157.1) - CDCR350789 from Creative Biomart

Species Human
Accession NM_001136157.1

Human OTUD5 ORF Clone(NM_001136158.1) - CDCR350790 from Creative Biomart

Species Human
Accession NM_001136158.1

Human OTUD5 ORF Clone(NM_001136159.1) - CDCR350791 from Creative Biomart

Species Human
Accession NM_001136159.1

Human OTUD5 ORF Clone(NM_001136159.1) - CDCR350792 from Creative Biomart

Species Human
Accession NM_001136159.1

Human OTUD5 ORF Clone(NM_001136158.1) - CDCR350795 from Creative Biomart

Species Human
Accession NM_001136158.1

Human OTUD5 ORF clone(NM_017602.3) - CDCH394795 from Creative biogene

Species Human

Human OTUD5 ORF Clone(NM_001136158.1) - CDCR350790 from Creative biogene

Species Human

Mouse OTUD5 ORF clone (NM_001136159.1) - CDCL145101 from Creative biogene

Species Human

Mouse OTUD5 ORF clone (NM_001136157.1) - CDCL145103 from Creative biogene

Species Human

Human OTUD5 cDNA Clone(NM_001136157.1) - CDFH013527 from Creative biogene

Species Human

Human OTUD5 cDNA Clone(NM_001136158.1) - CDFH013528 from Creative biogene

Species Human

Human OTUD5 cDNA Clone(NM_001136159.1) - CDFH013529 from Creative biogene

Species Human
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