| Gene Symbol |
KCNA5
|
| Entrez Gene |
3741
|
| Alt Symbol |
ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, voltage gated shaker related subfamily A, member 5
|
| Other Description |
cardiac potassium channel|insulinoma and islet potassium channel|potassium channel 1|potassium voltage-gated channel subfamily A member 5|potassium voltage-gated channel, shaker-related subfamily, member 5|voltage-gated potassium channel HK2|voltage-gated potassium channel protein Kv1.5|voltage-gated potassium channel subunit Kv1.5
|
| Swissprots |
Q4KKT8 Q9UDA4 Q4VAJ1 P22460 Q4VAJ2
|
| Accessions |
EAW88830 P22460 BC096357 AAH96357 BC096358 AAH96358 BC099665 AAH99665 BC099666 AAH99666 BM663787 BM692565 M55513 AAA36422 M60451 AAA61276 M83254 AAA60146 NM_002234 NP_002225
|
| Function |
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic is
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:8505626}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Pancreatic islets and insulinoma.
|