KCNA5
| Gene Symbol | KCNA5 |
|---|---|
| Entrez Gene | 3741 |
| Alt Symbol | ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, voltage gated shaker related subfamily A, member 5 |
| Other Description | cardiac potassium channel|insulinoma and islet potassium channel|potassium channel 1|potassium voltage-gated channel subfamily A member 5|potassium voltage-gated channel, shaker-related subfamily, member 5|voltage-gated potassium channel HK2|voltage-gated potassium channel protein Kv1.5|voltage-gated potassium channel subunit Kv1.5 |
| Swissprots | Q4KKT8 Q9UDA4 Q4VAJ1 P22460 Q4VAJ2 |
| Accessions | EAW88830 P22460 BC096357 AAH96357 BC096358 AAH96358 BC099665 AAH99665 BC099666 AAH99666 BM663787 BM692565 M55513 AAA36422 M60451 AAA61276 M83254 AAA60146 NM_002234 NP_002225 |
| Function | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic is |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:8505626}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Pancreatic islets and insulinoma. |
KV1.5 CRISPR/Cas9 KO Plasmid (h) - sc-404341 from Santa Cruz Biotechnology
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KV1.5 HDR Plasmid (h) - sc-404341-HDR from Santa Cruz Biotechnology
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KV1.5 Double Nickase Plasmid (h) - sc-404341-NIC from Santa Cruz Biotechnology
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KV1.5 Double Nickase Plasmid (h2) - sc-404341-NIC-2 from Santa Cruz Biotechnology
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KV1.5 CRISPR Activation Plasmid (h) - sc-404341-ACT from Santa Cruz Biotechnology
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KV1.5 CRISPR Activation Plasmid (h2) - sc-404341-ACT-2 from Santa Cruz Biotechnology
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KV1.5 Lentiviral Activation Particles (h) - sc-404341-LAC from Santa Cruz Biotechnology
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KV1.5 Lentiviral Activation Particles (h2) - sc-404341-LAC-2 from Santa Cruz Biotechnology
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KV1.5 siRNA (h) - sc-42716 from Santa Cruz Biotechnology
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KV1.5 shRNA Plasmid (h) - sc-42716-SH from Santa Cruz Biotechnology
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KV1.5 shRNA (h) Lentiviral Particles - sc-42716-V from Santa Cruz Biotechnology
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Hexokinase 2 RNAi - H00003099-R02 from Novus Biologicals
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Kv1.5 RNAi - H00003741-R01 from Novus Biologicals
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MISSION® esiRNA - EHU118431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2068 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2068 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06850 from Sigma-Aldrich
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KCNA5 siRNA (Human) - CRH2517 from Cohesion Biosciences
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KCNA5, siRNA - MBS8216145 from MyBioSource
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KV1.5 CRISPR/Cas9 KO Plasmid (h2) - sc-404341-KO-2 from Santa Cruz Biotechnology
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KV1.5 HDR Plasmid (h2) - sc-404341-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human KCNA5 (NM_002234.3) - SHH322735 from Creative biogene
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KCNA5 shRNA Plasmid (Human) - CHH2517 from Cohesion Biosciences
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KCNA5 miRNA 3'UTR clone - MiUTR3H-01800 from Creative biogene
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