| Gene Symbol |
DERL3
|
| Entrez Gene |
91319
|
| Alt Symbol |
C22orf14, IZP6, LLN2, derlin-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
derlin 3
|
| Other Description |
DERtrin 3|DERtrin-3|Der1-like domain family, member 3|degradation in endoplasmic reticulum protein 3|der1-like protein 3|derlin-3
|
| Swissprots |
Q6ZUB5 F2Z3B6 Q6PEX0 Q96Q80 Q6ICJ6
|
| Accessions |
BAB68409 EAW59609 EAW59610 EAW59611 EAW59612 Q96Q80 AA985493 AK092582 AK096976 BAC04919 AK125830 BAC86311 AL389876 AW135031 BC057830 AAH57830 BM792257 CA313370 CR456372 CAG30258 CU013077 CAK54508 CU013365 CAK54807 T79532 XM_011530503 XP_011528805 XM_011530504 XP_011528806 XM_011530505 XP_011528807 XM_011530506 XP_011528808 XM_011530507 XP_011528809 XM_011546910 XP_011545212 XM_011546911 XP_011545213 XM_011546912 XP_011545214 XM_011546913 XP_011545215 XM_011546914 XP_011545216 NM_001002862 NP_001002862 NM_001135751 NP_001129223 NM_198440 NP_940842
|
| Function |
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. {ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:22607976}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:16449189}.
|
| Tissue Specificity |
Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine. {ECO:0000269|PubMed:16449189}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|