DERL3

Gene Symbol DERL3
Entrez Gene 91319
Alt Symbol C22orf14, IZP6, LLN2, derlin-3
Species Human
Gene Type protein-coding
Description derlin 3
Other Description DERtrin 3|DERtrin-3|Der1-like domain family, member 3|degradation in endoplasmic reticulum protein 3|der1-like protein 3|derlin-3
Swissprots Q6ZUB5 F2Z3B6 Q6PEX0 Q96Q80 Q6ICJ6
Accessions BAB68409 EAW59609 EAW59610 EAW59611 EAW59612 Q96Q80 AA985493 AK092582 AK096976 BAC04919 AK125830 BAC86311 AL389876 AW135031 BC057830 AAH57830 BM792257 CA313370 CR456372 CAG30258 CU013077 CAK54508 CU013365 CAK54807 T79532 XM_011530503 XP_011528805 XM_011530504 XP_011528806 XM_011530505 XP_011528807 XM_011530506 XP_011528808 XM_011530507 XP_011528809 XM_011546910 XP_011545212 XM_011546911 XP_011545213 XM_011546912 XP_011545214 XM_011546913 XP_011545215 XM_011546914 XP_011545216 NM_001002862 NP_001002862 NM_001135751 NP_001129223 NM_198440 NP_940842
Function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. {ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:22607976}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:16449189}.
Tissue Specificity Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine. {ECO:0000269|PubMed:16449189}.
Top Pathways Protein processing in endoplasmic reticulum

Derlin-3 (L-14) - sc-50827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Derlin-3 (P-13) - sc-50828 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DERL3 antibody - ab78233 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of formalin-fixed, paraffin embedded Human pancreas tissue using ab78233 at 20µg/ml.

Anti-DERL3 antibody - ab106296 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL3 antibody - ab54587 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Derlin-3 / DERL3 Antibody (aa71-120) - LS-C110945 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DERL3 antibody LS-C110945 Western blot of 1 Cell lysate. Antibody concentration 1 ug/ml.

Anti-Derlin-3 / DERL3 Antibody (C-Terminus) - LS-C80661 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-Derlin-3 / DERL3 Antibody (N-Terminus) IHC-plus™ - LS-B1826 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-DERL3 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1826 concentration 20 ug/ml.

Anti-Derlin-3 / DERL3 Antibody (N-Terminus) - LS-C144797 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Derlin-3 / DERL3 Antibody (N-Terminus) - LS-C153435 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Derlin-3 Antibody - NBP1-59467 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Derlin-3 Antibody [NBP1-59467] - Human Muscle lysate, concentration 0.2-1 ug/ml.

Derlin-3 Antibody - NBP1-59466 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Derlin-3 Antibody [NBP1-59466] - THP-1 cell lysate, concentration 0.2-1 ug/ml.

Derlin-3 Antibody - NBP2-16152 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL3 antibody produced in rabbit - SAB2701545 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DERL3: <B>Cat. No. SAB2701545</B>: Western Blot analysis of DERL3 in extracts from <B>Lanes</B><BR/>A. U87-MG using <B>Cat. No. SAB2701545</B> at a 1:1000 dilution.

Anti-DERL3 antibody produced in rabbit - HPA049306 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DERL3: <B>Cat. No. HPA049306</B>: Immunohistochemical staining of Human lymph node shows strong cytoplasmic positivity in a subset of germinal center cells.

Anti-Derlin-3 antibody produced in rabbit - D2194 from Sigma-Aldrich

Prices $59.70, $346.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>HeLa cells were fixed and permeabilized with 4% paraformaldehyde followed by 0.5% Triton X-100. Fixed cells were stained with 20 μg/mL Rabbit Anti-Derlin-3 (<B>Cat. No. D2194</B>). The antibody was developed using Goat Anti-Rabbit IgG, Cy3 conjugate.

Anti-DERL3 antibody produced in rabbit - SAB2100563 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DERL3: <B>Cat. No.SAB2100563</B>: DERL3 in Fetal Muscle tissue lysate with DERL3 antibody at 1.0 μg/mL.

DERL3 antibody - middle region (ARP44442_P050) - ARP44442_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DERL3 antibody - C-terminal region (ARP44443_P050) - ARP44443_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

derl3 antibody - zf125048 from GeneTex

Host Rabbit
Clonality Polyclonal

DERL3 antibody [N3C2], Internal - GTX122163 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-DERL3 antibody [N3C2], Internal used in Western blot. GTX122163

DERL3 antibody - 70R-6366 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

DERL3 Antibody (OALA02182) - OALA02182 from Aviva Systems Biology

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

DERL3 antibody - 70R-6365 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Derlin-3 (N-term) antibody - AP08308PU-N from Acris Antibodies

Prices $430.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Pancreas: Formalin-Fixed Paraffin Embedded (FFPE)
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