DERL3

Gene Symbol	DERL3
Entrez Gene	91319
Alt Symbol	C22orf14, IZP6, LLN2, derlin-3
Species	Human
Gene Type	protein-coding
Description	derlin 3
Other Description	DERtrin 3|DERtrin-3|Der1-like domain family, member 3|degradation in endoplasmic reticulum protein 3|der1-like protein 3|derlin-3
Swissprots	Q6ZUB5 F2Z3B6 Q6PEX0 Q96Q80 Q6ICJ6
Accessions	BAB68409 EAW59609 EAW59610 EAW59611 EAW59612 Q96Q80 AA985493 AK092582 AK096976 BAC04919 AK125830 BAC86311 AL389876 AW135031 BC057830 AAH57830 BM792257 CA313370 CR456372 CAG30258 CU013077 CAK54508 CU013365 CAK54807 T79532 XM_011530503 XP_011528805 XM_011530504 XP_011528806 XM_011530505 XP_011528807 XM_011530506 XP_011528808 XM_011530507 XP_011528809 XM_011546910 XP_011545212 XM_011546911 XP_011545213 XM_011546912 XP_011545214 XM_011546913 XP_011545215 XM_011546914 XP_011545216 NM_001002862 NP_001002862 NM_001135751 NP_001129223 NM_198440 NP_940842
Function	Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. {ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:22607976}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:16449189}.
Tissue Specificity	Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine. {ECO:0000269|PubMed:16449189}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DERL3 full length protein - ab164849 from Abcam Category Protein Source Wheat germ Species Human

Derlin-3 / DERL3 Antibody Blocking Peptide - LS-E16323 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Derlin-3 Protein - H00091319-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DERL3 Blocking Peptide - 33R-2886 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DERL3 Blocking Peptide - 33R-10295 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Derlin-3 - H00091319-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Derlin-3 - H00091319-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DERL3 fusion protein - ag6784 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

DERL3 fusion protein - ag6161 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

DERL3-Antibody-C-term-Blocking-peptide - BP5908b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DERL3 Peptide, Human - M34GP04232H from Creative Peptides Category Peptide Source Synthetic. Species Human

Derlin-3 (DERL3), Recombinant Protein - MBS7013717 from MyBioSource Category Protein Prices $1,050.00, $2,035.00, $3,245.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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