DERL3

Gene Symbol DERL3
Entrez Gene 91319
Alt Symbol C22orf14, IZP6, LLN2, derlin-3
Species Human
Gene Type protein-coding
Description derlin 3
Other Description DERtrin 3|DERtrin-3|Der1-like domain family, member 3|degradation in endoplasmic reticulum protein 3|der1-like protein 3|derlin-3
Swissprots Q6ZUB5 F2Z3B6 Q6PEX0 Q96Q80 Q6ICJ6
Accessions BAB68409 EAW59609 EAW59610 EAW59611 EAW59612 Q96Q80 AA985493 AK092582 AK096976 BAC04919 AK125830 BAC86311 AL389876 AW135031 BC057830 AAH57830 BM792257 CA313370 CR456372 CAG30258 CU013077 CAK54508 CU013365 CAK54807 T79532 XM_011530503 XP_011528805 XM_011530504 XP_011528806 XM_011530505 XP_011528807 XM_011530506 XP_011528808 XM_011530507 XP_011528809 XM_011546910 XP_011545212 XM_011546911 XP_011545213 XM_011546912 XP_011545214 XM_011546913 XP_011545215 XM_011546914 XP_011545216 NM_001002862 NP_001002862 NM_001135751 NP_001129223 NM_198440 NP_940842
Function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. {ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:22607976}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:16449189}.
Tissue Specificity Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine. {ECO:0000269|PubMed:16449189}.
Top Pathways Protein processing in endoplasmic reticulum

Derlin-3 CRISPR/Cas9 KO Plasmid (h) - sc-413887 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-3 HDR Plasmid (h) - sc-413887-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-3 Double Nickase Plasmid (h) - sc-413887-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-3 Double Nickase Plasmid (h2) - sc-413887-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-3 CRISPR Activation Plasmid (h) - sc-413887-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-3 CRISPR Activation Plasmid (h2) - sc-413887-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-3 Lentiviral Activation Particles (h) - sc-413887-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-3 Lentiviral Activation Particles (h2) - sc-413887-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Derlin-3 siRNA (h) - sc-60523 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Derlin-3 shRNA Plasmid (h) - sc-60523-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Derlin-3 shRNA (h) Lentiviral Particles - sc-60523-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU141501 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU097161 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7157 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7157 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11675 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11675

DERL3 siRNA (Human) - CRJ4028 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DERL3 - MBS8237028 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DERL3 (NM_198440.3) - SHH277229 from Creative biogene

Category siRNA
Species Reactivities Human

DERL3 shRNA Plasmid (Human) - CHJ4028 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DERL3 miRNA 3'UTR clone - MiUTR3H-11145 from Creative biogene

Species Reactivities Human

DERL3 miRNA 3'UTR clone - MiUTR4H-TG02690 from Creative biogene

Species Reactivities Human
Search more