| Gene Symbol |
PPM1D
|
| Entrez Gene |
8493
|
| Alt Symbol |
PP2C-DELTA, WIP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase, Mg2+/Mn2+ dependent, 1D
|
| Other Description |
protein phosphatase 1D|protein phosphatase 1D magnesium-dependent, delta isoform|protein phosphatase 2C delta isoform|protein phosphatase Wip1|wild-type p53-induced phosphatase 1
|
| Swissprots |
Q53XP4 O15297 Q8IVR6 Q6P991
|
| Accessions |
EAW51408 EAW51409 O15297 AA326266 AK054573 AK299773 BAG61656 AK312902 BAG35748 AU280469 BC016480 AAH16480 BC032826 BC033893 AAH33893 BC042418 AAH42418 BC060877 AAH60877 BT009780 AAP88782 BU616782 DQ891047 ABM81973 EU176552 ABW03353 U78305 AAB61637 XR_934577 NM_003620 NP_003611
|
| Function |
Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. {ECO:0000269|PubMed:15870257, ECO:0000269|PubMed:16311512}.
|
| Top Pathways |
p53 signaling pathway
|