PPM1D

Gene Symbol	PPM1D
Entrez Gene	8493
Alt Symbol	PP2C-DELTA, WIP1
Species	Human
Gene Type	protein-coding
Description	protein phosphatase, Mg2+/Mn2+ dependent, 1D
Other Description	protein phosphatase 1D|protein phosphatase 1D magnesium-dependent, delta isoform|protein phosphatase 2C delta isoform|protein phosphatase Wip1|wild-type p53-induced phosphatase 1
Swissprots	Q53XP4 O15297 Q8IVR6 Q6P991
Accessions	EAW51408 EAW51409 O15297 AA326266 AK054573 AK299773 BAG61656 AK312902 BAG35748 AU280469 BC016480 AAH16480 BC032826 BC033893 AAH33893 BC042418 AAH42418 BC060877 AAH60877 BT009780 AAP88782 BU616782 DQ891047 ABM81973 EU176552 ABW03353 U78305 AAB61637 XR_934577 NM_003620 NP_003611
Function	Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. {ECO:0000269|PubMed:15870257, ECO:0000269|PubMed:16311512}.
Top Pathways	p53 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Wip1 CRISPR/Cas9 KO Plasmid (h) - sc-400980 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Wip1 HDR Plasmid (h) - sc-400980-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Wip1 Double Nickase Plasmid (h) - sc-400980-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Wip1 Double Nickase Plasmid (h2) - sc-400980-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Wip1 CRISPR Activation Plasmid (h) - sc-400980-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Wip1 CRISPR Activation Plasmid (h2) - sc-400980-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Wip1 Lentiviral Activation Particles (h) - sc-400980-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Wip1 Lentiviral Activation Particles (h2) - sc-400980-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Wip1 siRNA (h) - sc-39205 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Wip1 shRNA Plasmid (h) - sc-39205-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Wip1 shRNA (h) Lentiviral Particles - sc-39205-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PPM1D RNAi - H00008493-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU009271 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0482 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0481 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0483 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN1291 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1291 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08016 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08016

PPM1D siRNA (Human) - CRH5568 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PPM1D (NM_003620.3) - SHH380808 from Creative biogene Category siRNA Species Reactivities Human

Human PPM1D siRNA - orb266070 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PPM1D shRNA Plasmid (Human) - CHH5568 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PPM1D miRNA 3'UTR clone - MiUTR3H-07373 from Creative biogene Species Reactivities Human

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