JAM3

Gene Symbol	JAM3
Entrez Gene	83700
Alt Symbol	JAM-2, JAM-3, JAM-C, JAMC
Species	Human
Gene Type	protein-coding
Description	junctional adhesion molecule 3
Other Description	junctional adhesion molecule C
Swissprots	Q96FL1 Q8WWL8 B3KWG9 Q9BX67
Accessions	CAF85939 CAF86920 CBX47566 CCA65346 EAW67817 EAW67818 EAW67819 EAW67820 Q9BX67 AF356518 AAK27221 AF448478 AAM20925 AJ344431 CAC69845 AJ416101 CAC94776 AK027435 AK074769 BAC11195 AK075309 BAC11538 AK125071 BAG54131 AK225666 AY358335 AAQ88701 BC010690 AAH10690 BC012147 AAH12147 BC057284 BC063031 W76344 NM_001205329 NP_001192258 NM_032801 NP_116190
Function	Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis. {ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:20592283}.
Subcellular Location	Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, desmosome. Secreted, extracellular space. Note=In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts.
Tissue Specificity	Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level). {ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:11944976, ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:15994945, ECO:0000269|PubMed:20592283}.
Top Pathways	Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Epithelial cell signaling in Helicobacter pylori infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JAM-C (C-15) - sc-23006 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

JAM-C (F-12) - sc-23005 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

JAM-C (F26) - sc-52691 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rat Clonality Monoclonal

JAM-C (H36) - sc-52692 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rat Clonality Monoclonal

JAM-C (CRAM-19 H36) - sc-73571 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rat Clonality Monoclonal

JAM-C (CRAM-18 F26) - sc-73570 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rat Clonality Monoclonal

JAM-C (13Y07) - sc-80134 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-Junctional Adhesion Molecule C antibody - ab81331 from Abcam Prices $380.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Junctional Adhesion Molecule C antibody [19 H36] - ab16889 from Abcam Prices $370.00 Sizes 50 µg Host Rat Clonality Monoclonal Clone 19 H36

Anti-Junctional Adhesion Molecule C antibody [CRAM-18 F26] - ab16906 from Abcam Prices $370.00 Sizes 50 µg Host Rat Clonality Monoclonal Clone CRAM-18 F26

Anti-Junctional Adhesion Molecule C antibody [MM0426-4M35] - ab89665 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone MM0426-4M35

Anti-Junctional Adhesion Molecule C antibody - C-terminal - ab188348 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-JAM3 Antibody - LS-C16118 from LifeSpan Bioscience Prices $695.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-JAM3 Antibody - LS-C16119 from LifeSpan Bioscience Prices $695.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-JAM3 Antibody (aa276-289) - LS-C112657 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-JAM3 Antibody - LS-C123926 from LifeSpan Bioscience Prices $710.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-JAM3 Antibody (clone CRAM-19 H36) - LS-C139895 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-JAM3 Antibody (clone CRAM-18 F26) - LS-C139896 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-JAM3 Antibody (clone CRAM-18 F26, Azide-free) - LS-C187592 from LifeSpan Bioscience Prices $865.00 Sizes 1 mg Host Rat Clonality Monoclonal

Anti-JAM3 Antibody (clone CRAM-18 F26, Biotin) - LS-C187590 from LifeSpan Bioscience Prices $350.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-JAM3 Antibody (Cytoplasmic Domain) - LS-C190098 from LifeSpan Bioscience Prices $495.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-JAM3 Antibody (clone 18F26) - LS-C202269 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rat Clonality Monoclonal Clone 18F26

Anti-JAM3 Antibody (aa36-85) - LS-C81519 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-JAM3 Antibody (aa82-180) - LS-C308571 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-JAM3 Antibody - LS-C310815 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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