JAM3

Gene Symbol	JAM3
Entrez Gene	83700
Alt Symbol	JAM-2, JAM-3, JAM-C, JAMC
Species	Human
Gene Type	protein-coding
Description	junctional adhesion molecule 3
Other Description	junctional adhesion molecule C
Swissprots	Q96FL1 Q8WWL8 B3KWG9 Q9BX67
Accessions	CAF85939 CAF86920 CBX47566 CCA65346 EAW67817 EAW67818 EAW67819 EAW67820 Q9BX67 AF356518 AAK27221 AF448478 AAM20925 AJ344431 CAC69845 AJ416101 CAC94776 AK027435 AK074769 BAC11195 AK075309 BAC11538 AK125071 BAG54131 AK225666 AY358335 AAQ88701 BC010690 AAH10690 BC012147 AAH12147 BC057284 BC063031 W76344 NM_001205329 NP_001192258 NM_032801 NP_116190
Function	Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis. {ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:20592283}.
Subcellular Location	Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, desmosome. Secreted, extracellular space. Note=In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts.
Tissue Specificity	Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level). {ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:11944976, ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:15994945, ECO:0000269|PubMed:20592283}.
Top Pathways	Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Epithelial cell signaling in Helicobacter pylori infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Junctional Adhesion Molecule C protein fragment - ab134536 from Abcam Category Protein Source E. coli Species Human

JAM3 Antibody Blocking Peptide - LS-E18107 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JAM3 Antibody Blocking Peptide - LS-E27059 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human JAM-C Protein - NBP2-23160 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Source E.coli Species Human

JAM-C Recombinant Protein - H00083700-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg

JAM3-Antibody-C-term-Blocking-Peptide - BP6766b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JAMC blocking peptide - GTX88216-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

Recombinant Human JAM-C Fc Chimera, CF - 1189-J3-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human JAM-C protein - orb139235 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human JAM-C protein - orb139236 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

JAM2 protein (His tag) - 30R-2938 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

JAM3 Blocking Peptide - 33R-8834 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

JAM3 protein (His tag) - 80R-2475 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

Junctional Adhesion Molecule C Peptide - AC21-1881-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

JAM3 / JAM-C (32-241, His-tag) - AR50547PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

JAM3 / JAM-C (32-241, His-tag) - AR50547PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

JAM3 / JAM-C - H00083700-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

JAM3 / JAM-C - H00083700-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

JAM3, 32-241aa Human, His tag, E.coli - 01-P1723 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

Junctional Adhesion Molecule 3 (JAM3), Human - 20-9478 from ARP American Research Products Category Protein Prices $429.00 Sizes 50 µg Source E.coli Species Human

JAM3 Peptide - 42-292P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

JAM3 Human - PRPS-1230 from NeoScientific Category Protein Prices $65.00, $169.00, $1,560.00 Sizes 2 µg, 10 µg, 100 µg Source E.coli. Species Human

Recombinant Human Junctional Adhesion Molecule 3, His-tagged - JAM3-7155H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Junctional Adhesion Molecule 3 (JAM3) - RPL637Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Junctional Adhesion Molecule 3 (JAM3) - RPL637Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

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