JAM3

Gene Symbol	JAM3
Entrez Gene	83700
Alt Symbol	JAM-2, JAM-3, JAM-C, JAMC
Species	Human
Gene Type	protein-coding
Description	junctional adhesion molecule 3
Other Description	junctional adhesion molecule C
Swissprots	Q96FL1 Q8WWL8 B3KWG9 Q9BX67
Accessions	CAF85939 CAF86920 CBX47566 CCA65346 EAW67817 EAW67818 EAW67819 EAW67820 Q9BX67 AF356518 AAK27221 AF448478 AAM20925 AJ344431 CAC69845 AJ416101 CAC94776 AK027435 AK074769 BAC11195 AK075309 BAC11538 AK125071 BAG54131 AK225666 AY358335 AAQ88701 BC010690 AAH10690 BC012147 AAH12147 BC057284 BC063031 W76344 NM_001205329 NP_001192258 NM_032801 NP_116190
Function	Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis. {ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:20592283}.
Subcellular Location	Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, desmosome. Secreted, extracellular space. Note=In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts.
Tissue Specificity	Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level). {ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:11944976, ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:15994945, ECO:0000269|PubMed:20592283}.
Top Pathways	Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Epithelial cell signaling in Helicobacter pylori infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human JAM3 Gene cDNA Clone - orb143921 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human JAM3 ORF clone(NM_032801.4) - CDCH387494 from Creative Biomart Species Human Accession NM_032801.4

Human JAM3 ORF Clone(NM_032801.4) - CDCL167554 from Creative Biomart Species Human Accession NM_032801.4

Human JAM3 ORF Clone(NM_001205329.1) - CDCL167555 from Creative Biomart Species Human Accession NM_001205329.1

Human JAM-C/JAM3 Gene ORF cDNA clone in cloning vector - HG13152-G from Sino Biological Species Human

Human JAM-C/JAM3 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13152-NY from Sino Biological Species Human

Human JAM-C/JAM3 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13152-NF from Sino Biological Species Human

Human JAM-C/JAM3 Gene ORF cDNA clone expression plasmid, N-His tag - HG13152-NH from Sino Biological Species Human

Human JAM-C/JAM3 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13152-NM from Sino Biological Species Human

Human JAM-C/JAM3 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13152-CF from Sino Biological Species Human

Human JAM-C/JAM3 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13152-CM from Sino Biological Species Human

Human JAM-C/JAM3 Gene ORF cDNA clone expression plasmid, C-His tag - HG13152-CH from Sino Biological Species Human

Human JAM-C/JAM3 Gene ORF cDNA clone expression plasmid - HG13152-UT from Sino Biological Species Human

Human JAM-C/JAM3 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13152-ACG from Sino Biological Species Human

Human JAM-C/JAM3 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13152-CY from Sino Biological Species Human

Human JAM3 ORF clone(NM_032801.4) - CDCH387494 from Creative biogene Species Human

Human JAM3 ORF clone (NM_032801.3) - CDCB160238 from Creative biogene Species Human

Human JAM-C (NP_116190) VersaClone cDNA - RDC1620 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

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