KDM2A

Gene Symbol KDM2A
Entrez Gene 22992
Alt Symbol CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 2A
Other Description CXXC-type zinc finger protein 8|F-box and leucine-rich repeat protein 11|F-box/LRR-repeat protein 11|[Histone-H3]-lysine-36 demethylase 1A|jmjC domain-containing histone demethylation protein 1A|jumonji C domain-containing histone demethylase 1A|lysine-specific demethylase 2A
Swissprots Q69YY8 Q4G0M3 I3VM55 E9PIL6 Q9UK66 D4QA03 Q9BVH5 Q9Y2K7 Q9H7H5 Q49A21
Accessions CCO13754 EAW74578 EAW74579 EAW74580 Q9Y2K7 AB023221 BAA76848 AB490246 BAJ05817 AF179221 AAD56012 AI185920 AK022684 AK024505 BAB15795 AK128293 AK299725 BAG61623 AL117517 CAH10721 BC001203 AAH01203 BC027467 BC047371 AAH47371 BC047486 AAH47486 BC056905 BC064360 AAH64360 BE675843 DR001963 JQ710741 AFK81540 JQ710742 AFK81541 JQ710743 AFK81542 JQ710744 AFK81543 XM_006718479 XP_006718542 XM_006718480 XP_006718543 XM_011544860 XP_011543162 XM_011544861 XP_011543163 XM_011544862 XP_011543164 NM_001256405 NP_001243334 NM_012308 NP_036440 NR_027473
Function Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.
Tissue Specificity Widely expressed, with highest levels in brain, testis and ovary, followed by lung. {ECO:0000269|PubMed:10231032}.

FBL11 (H-120) - sc-135126 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FBL11 (H-120): sc-135126. Western blot analysis of FBL11 expression in HeLa (A), IMR-32 (B) and SH-SY5Y (C) nuclear extracts.

FBL11 (N-21) - sc-130585 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
FBL11 (N-21): sc-130585. Western blot analysis of FBL11 expression in non-transfected (A) and human FBL11 transfected (B) 293 whole cell lysates.

FBL11 (N-14) - sc-240452 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FBL11 (N-14): sc-240452. Western blot analysis of FBL11 expression in Jurkat whole cell lysate.

Anti-FBXL11 antibody - ab172401 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-FBXL11 antibody (ab172401) at 1 µg/mlLane 1 : FBXL11 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-FBXL11 antibody - ChIP Grade - ab31739 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FBXL11 antibody - ChIP Grade (ab31739) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 3 : HeLa (Human epithelial carcinoma cell line) Nuclear LysateLysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Rabbit IgG (Alexa Fluor® 680) at 1/10000 dilutionPerformed under reducing conditions.

Anti-FBXL11 antibody - N-terminal - ab71349 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-FBXL11 antibody - N-terminal (ab71349) at 1/50 dilutionLane 1 : Nontransfected 293 cell lysatesLane 2 : 293 cell lysates transiently transfected with the KDM2 / JHD1 geneLysates/proteins at 2 µg per lane.

Anti-JHDM1A / KDM2A Antibody (Internal) - LS-C145115 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-JHDM1A / KDM2A Antibody (Biotin) - LS-C180856 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-JHDM1A / KDM2A Antibody (DY650) - LS-C180857 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-JHDM1A / KDM2A Antibody (DY488) - LS-C180858 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-JHDM1A / KDM2A Antibody (DY550) - LS-C180859 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-JHDM1A / KDM2A Antibody (aa1112-1162) - LS-C288270 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-JHDM1A / KDM2A Antibody (N-Terminus) - LS-C30281 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KDM2A / FBXL11 antibody LS-C30281 was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.

Anti-JHDM1A / KDM2A Antibody (aa867-896) - LS-C159949 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-JHDM1a/FBXL11 Antibody pre-incubated with(right lane) and without(left lane) blocking peptide in Jurkat cell line lysate. JHDM1a(arrow) was detected using the purified antibody.

Anti-JHDM1A / KDM2A Antibody (aa1023-1072) - LS-C201712 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HepG2. KDM2A antibody dilution 1.0 ug/ml.

Anti-JHDM1A / KDM2A Antibody (aa825-875) - LS-C286740 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human JHDM1A Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-JHDM1A used at a dilution of 1:250.

Anti-JHDM1A / KDM2A Antibody (aa825-875) - LS-C288281 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human JHDM1A by Immunohistochemistry. Sample: FFPE section of human stomach carcinoma. Antibody: Affinity purified rabbit anti-JHDM1A used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

Anti-JHDM1A / KDM2A Antibody (aa139-153) IHC-plus™ - LS-B8683 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-JHDM1A / KDM2A antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-JHDM1A / KDM2A Antibody - LS-C180164 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: KDM2A/FBXL11 Antibody - IHC of KDM2A / FBXL11 in human kidney cancer xenograft using DAB with hematoxylin counterstain.

Anti-JHDM1A / KDM2A Antibody (aa500-527) - LS-C96586 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human testis tissue reacted with JHDM1a/FBXL11 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

KDM2A/FBXL11 Antibody - NB100-74602 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: KDM2A/FBXL11 Antibody [NB100-74602] - Sample: FFPE section of human lung cancer. Antibody: Affinity purified rabbit anti- JHDM1A used at a dilution of 1:1,000 (1ug/ml). Detection: DAB

KDM2A/FBXL11 Antibody - NBP1-78305 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: KDM2A/FBXL11 Antibody [NBP1-78305] - Antibody was tested in HeLa cells with FITC (green). Nuclei were counterstained with DAPI (blue).

KDM2A/FBXL11 Antibody - NBP1-31502 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Immunohistochemistry: KDM2A/FBXL11 Antibody [NBP1-31502] - Paraffin-embedded Lung Blood Vessel, using NBP1-31502 at 1:100 dilution.

KDM2A/FBXL11 Antibody - NBP2-27554 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: KDM2A/FBXL11 Antibody [NBP2-27554] - (0.5 ug/ml) staining of Human Uterus lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

KDM2A/FBXL11 Antibody - NBP1-44076 from Novus Biologicals

Prices $329.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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