| Gene Symbol |
KDM2A
|
| Entrez Gene |
22992
|
| Alt Symbol |
CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 2A
|
| Other Description |
CXXC-type zinc finger protein 8|F-box and leucine-rich repeat protein 11|F-box/LRR-repeat protein 11|[Histone-H3]-lysine-36 demethylase 1A|jmjC domain-containing histone demethylation protein 1A|jumonji C domain-containing histone demethylase 1A|lysine-specific demethylase 2A
|
| Swissprots |
Q69YY8 Q4G0M3 I3VM55 E9PIL6 Q9UK66 D4QA03 Q9BVH5 Q9Y2K7 Q9H7H5 Q49A21
|
| Accessions |
CCO13754 EAW74578 EAW74579 EAW74580 Q9Y2K7 AB023221 BAA76848 AB490246 BAJ05817 AF179221 AAD56012 AI185920 AK022684 AK024505 BAB15795 AK128293 AK299725 BAG61623 AL117517 CAH10721 BC001203 AAH01203 BC027467 BC047371 AAH47371 BC047486 AAH47486 BC056905 BC064360 AAH64360 BE675843 DR001963 JQ710741 AFK81540 JQ710742 AFK81541 JQ710743 AFK81542 JQ710744 AFK81543 XM_006718479 XP_006718542 XM_006718480 XP_006718543 XM_011544860 XP_011543162 XM_011544861 XP_011543163 XM_011544862 XP_011543164 NM_001256405 NP_001243334 NM_012308 NP_036440 NR_027473
|
| Function |
Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877}.
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.
|
| Tissue Specificity |
Widely expressed, with highest levels in brain, testis and ovary, followed by lung. {ECO:0000269|PubMed:10231032}.
|